Angiotensinogen gene variation in a population case-control study of preeclampsia/eclampsia in Australians and Chinese

Thr) of AGT using allele-specific PCR and allele-induced restriction site PCR. The allele distributions of the microsatellite and the variant T235 of AGT were significantly different between the two ethnic groups. However, no significant allele associations were found with disease when comparing PE/E patients and controls in Australian or Chinese populations, which is in contrast to the two earlier reports. The results suggest that the contribution of AGT to the occurrence of PE/E is small, if anything, and is not constant across populations. -->

ISSN:	0173-0835
Přístupová URL adresa:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6881c0024dd53cc062033f6164bafe52 https://pubmed.ncbi.nlm.nih.gov/9378138
Rights:	CLOSED
Přírůstkové číslo:	edsair.doi.dedup.....6881c0024dd53cc062033f6164bafe52
Autor:	Hongyu Qiu, Yuliang Fu, Desmond W. Cooper, Alan N. Wilton, Guanglan Guo, Shaun P. Brennecke
Rok vydání:	1997
Předmět:	Candidate gene China Clinical Biochemistry Population Angiotensinogen Minisatellite Repeats Biology Biochemistry Polymerase Chain Reaction Analytical Chemistry Preeclampsia Gene Frequency Pre-Eclampsia Polymorphism (computer science) Pregnancy parasitic diseases medicine Humans Eclampsia Allele education Alleles Genetics education.field_of_study Case-control study Australia Genetic Variation medicine.disease Case-Control Studies Microsatellite Female
Zdroj:	Electrophoresis. 18(9)
ISSN:	0173-0835
Popis:	Preeclampsia/eclampsia (PE/E) is a common disease of human pregnancy with a strong genetic component. The etiology of PE/E is unknown. Two recent reports indicated that the angiotensinogen gene (AGT) could be involved in susceptibility to PE/E. We performed a population-based case-control study in Australian and Chinese populations to investigate whether AGT is a good candidate gene for PE/E. A microsatellite polymorphism within AGT was typed as well as a molecular variant T235 (Met-->Thr) of AGT using allele-specific PCR and allele-induced restriction site PCR. The allele distributions of the microsatellite and the variant T235 of AGT were significantly different between the two ethnic groups. However, no significant allele associations were found with disease when comparing PE/E patients and controls in Australian or Chinese populations, which is in contrast to the two earlier reports. The results suggest that the contribution of AGT to the occurrence of PE/E is small, if anything, and is not constant across populations.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6881c0024dd53cc062033f6164bafe52 https://pubmed.ncbi.nlm.nih.gov/9378138 Zobrazit plný text záznamu Plný text