Epidermal Growth Factor Receptor ( EGFR ) Mutation in Exon 19 (p.E749Q) Confers Resistance to Gefitinib in One Patient With Lung Adenocarcinoma

Autor:	Michela Visani, Dario de Biase, Giovanna Cavallo, Giovanni Tallini, Giorgia Acquaviva, Alba A. Brandes, Giovenzio Genestreti, Roberta Degli Esposti, Monica Di Battista, Thomas Brand, Annalisa Pession
Přispěvatelé:	Genestreti, Giovenzio, de Biase, Dario, Di Battista, Monica, Cavallo, Giovanna, Degli Esposti, Roberta, Visani, Michela, Acquaviva, Giorgia, Brand, Thoma, Pession, Annalisa, Tallini, Giovanni, Brandes, Alba A.
Rok vydání:	2017
Předmět:	Male Pulmonary and Respiratory Medicine Oncology Cancer Research medicine.medical_specialty Lung Neoplasms Drug-Related Side Effects and Adverse Reactions EGFR DNA Mutational Analysis Tyrosine kinase inhibitor Adenocarcinoma NSCLC 03 medical and health sciences Exon 0302 clinical medicine Gefitinib Next generation sequencing Internal medicine Humans Medicine 030212 general & internal medicine Epidermal growth factor receptor Lung cancer Protein Kinase Inhibitors Aged Lung biology business.industry High-Throughput Nucleotide Sequencing Exons medicine.disease Uncommon mutation ErbB Receptors Pleural Effusion Dyspnea medicine.anatomical_structure Drug Resistance Neoplasm Egfr mutation 030220 oncology & carcinogenesis Mutation Quinazolines Cancer research biology.protein business medicine.drug
Zdroj:	Clinical Lung Cancer. 18:e215-e217
ISSN:	1525-7304
Popis:	Clinical Practice Points • p.E749Q is an uncommon EGFR mutation in exon 19 with unknown clinical significance. • A patient with lung adenocarcinoma harboring the p.E749Q EGFR mutation does not respond to gefitinib. • The p.E749Q mutation seems to be correlated with resistance to tyrosine kinase inhibitors. • Conventional chemotherapy should be the treatment of choice in patients with the p.E749Q mutation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6881a2e18f7e81e31281dc84f96e9d55 https://doi.org/10.1016/j.cllc.2017.01.003 Zobrazit plný text záznamu Full Text from ScienceDirect