Brain-derived neurotrophic factor and nerve growth factor correlate with T-cell activation in primary Sjogren's syndrome

Autor: Fabrice Lalloué, Véronique Loustaud-Ratti, Ahmed Boumediene, Guillaume Gondran, Anne-Laure Fauchais, M.O. Jauberteau, Elisabeth Vidal
Přispěvatelé: Homéostasie Cellulaire et Pathologies (HCP), Université de Limoges (UNILIM)-CHU Limoges-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503), Service de Médecine interne A et polyclinique médicale [CHU Limoges], CHU Limoges, Service des Maladies infectieuses et tropicales [CHU Limoges], Physiologie Moléculaire de la Réponse Immune et des Lymphoproliférations (PMRIL), Université de Limoges (UNILIM)-Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503)-Centre National de la Recherche Scientifique (CNRS), Université de Limoges (UNILIM), Service d'Immunologie et immunogénétique [CHU Limoges]
Jazyk: angličtina
Rok vydání: 2009
Předmět:
CD4-Positive T-Lymphocytes
Male
T-Lymphocytes
CD8-Positive T-Lymphocytes
MESH: Brain-Derived Neurotrophic Factor
Severity of Illness Index
0302 clinical medicine
MESH: Aged
80 and over
Neurotrophic factors
B-Cell Activating Factor
Nerve Growth Factor
Immunology and Allergy
MESH: Nerve Growth Factor
Aged
80 and over
MESH: Aged
0303 health sciences
MESH: Middle Aged
MESH: CD4-Positive T-Lymphocytes
General Medicine
Middle Aged
[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism
MESH: CD8-Positive T-Lymphocytes
MESH: Case-Control Studies
3. Good health
Sjogren's Syndrome
medicine.anatomical_structure
[SDV.IMM]Life Sciences [q-bio]/Immunology
Female
Adult
medicine.medical_specialty
MESH: Lymphocyte Count
T cell
Immunology
Peripheral blood mononuclear cell
03 medical and health sciences
Rheumatology
Internal medicine
MESH: Severity of Illness Index
medicine
Humans
Lymphocyte Count
MESH: B-Cell Activating Factor
B-cell activating factor
B cell
Aged
030304 developmental biology
030203 arthritis & rheumatology
Brain-derived neurotrophic factor
MESH: Humans
business.industry
Brain-Derived Neurotrophic Factor
MESH: Biological Markers
MESH: Adult
HLA-DR Antigens
MESH: HLA-DR Antigens
MESH: Male
stomatognathic diseases
Nerve growth factor
Endocrinology
MESH: Sjogren's Syndrome
MESH: T-Lymphocytes
Case-Control Studies
business
MESH: Female
Biomarkers
CD8
Zdroj: Scandinavian Journal of Rheumatology
Scandinavian Journal of Rheumatology, Taylor & Francis, 2009, 38 (1), pp.50-7. ⟨10.1080/03009740802378832⟩
ISSN: 0300-9742
DOI: 10.1080/03009740802378832⟩
Popis: International audience; OBJECTIVES: Identification of factors associated with disease activity and B and T cell activation is a challenge in primary Sjogren's syndrome (pSS). Neurotrophins (NTs), recently reported as B cell antiapoptotic, and T-cell activation factors seem to be implicated in autoimmune diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). METHODS: Samples from 18 pSS patients and 12 control subjects were studied to determine serum levels of nerve-growth factor (NGF) and brain-derived neurotrophic factor (BDNF), and their relationships with T- and B-cell activation and disease activity. Peripheral blood mononuclear cells (PBMCs) from patients with pSS and controls were examined by flow cytometry for HLA-DR expression by activated T cells. B cell activation was evaluated by B cell activating factor (BAFF) serum levels measured by enzyme-linked immunosorbent assay (ELISA) and immunoglobulin (Ig) and free light chain (FLC) levels. RESULTS: Mean serum levels of BDNF in pSS patients were significantly higher than in healthy controls and correlated directly with disease activity. NGF levels were associated with the subgroup of patients with hypergammaglobulinaemia. The pSS group was characterized by peripheral CD4+ and CD8+ T cell activation that correlated positively with BDNF and NGF levels, respectively. CONCLUSION: NT levels are potential biomarkers for lymphocyte activation in pSS patients.
Databáze: OpenAIRE
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