The Multifaceted Functions of Autophagy in Breast Cancer Development and Treatment
| Autor: | Niklaus, Nicolas J, Tokarchuk, Igor, Zbinden, Mara, Schläfli, Anna M, Maycotte, Paola, Tschan, Mario P. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
tumor dormancy
autophagy therapy resistance Carcinogenesis QH301-705.5 EMT Breast Neoplasms 610 Medicine & health Review differentiation aggressiveness breast cancer subtypes Cell Transformation Neoplastic stem cells Cell Line Tumor Animals Humans 570 Life sciences biology metastasis Female Neoplasm Recurrence Local Biology (General) |
| Zdroj: | Cells, Vol 10, Iss 1447, p 1447 (2021) Niklaus, Nicolas J; Tokarchuk, Igor; Zbinden, Mara; Schläfli, Anna M; Maycotte, Paola; Tschan, Mario P. (2021). The Multifaceted Functions of Autophagy in Breast Cancer Development and Treatment. Cells, 10(6) MDPI 10.3390/cells10061447 Cells |
| ISSN: | 2073-4409 |
| DOI: | 10.3390/cells10061447 |
| Popis: | Macroautophagy (herein referred to as autophagy) is a complex catabolic process characterized by the formation of double-membrane vesicles called autophagosomes. During this process, autophagosomes engulf and deliver their intracellular content to lysosomes, where they are degraded by hydrolytic enzymes. Thereby, autophagy provides energy and building blocks to maintain cellular homeostasis and represents a dynamic recycling mechanism. Importantly, the clearance of damaged organelles and aggregated molecules by autophagy in normal cells contributes to cancer prevention. Therefore, the dysfunction of autophagy has a major impact on the cell fate and can contribute to tumorigenesis. Breast cancer is the most common cancer in women and has the highest mortality rate among all cancers in women worldwide. Breast cancer patients often have a good short-term prognosis, but long-term survivors often experience aggressive recurrence. This phenomenon might be explained by the high heterogeneity of breast cancer tumors rendering mammary tumors difficult to target. This review focuses on the mechanisms of autophagy during breast carcinogenesis and sheds light on the role of autophagy in the traits of aggressive breast cancer cells such as migration, invasion, and therapeutic resistance. |
| Databáze: | OpenAIRE |
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