The respiratory microbiome after lung transplantation: Reflection or driver of respiratory disease?
| Autor: | Caroline Cohen Eskind, Gowri Satyanarayana, Meghan H. Shilts, Suman R. Das, Ciara M. Shaver |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Graft Rejection
Lung Diseases Lung microbiome medicine.medical_treatment Population Disease 030230 surgery Article 03 medical and health sciences 0302 clinical medicine medicine Humans Immunology and Allergy Lung transplantation Pharmacology (medical) Microbiome education Lung Transplantation education.field_of_study business.industry Microbiota Respiratory disease respiratory system medicine.disease Transplant Recipients respiratory tract diseases Pneumonia medicine.anatomical_structure Immunology business Lung Transplantation |
| Zdroj: | Am J Transplant |
| ISSN: | 1600-6135 |
| DOI: | 10.1111/ajt.16568 |
| Popis: | With the introduction of high-throughput sequencing methods, our understanding of the human lower respiratory tract’s inhabitants has expanded significantly in recent years. What is now termed the ‘lung microbiome’ has been described for healthy patients, as well as people with chronic lung diseases and lung transplants. The lung microbiome of lung transplant recipients has proven to be unique compared to non-transplant patients, with characteristic findings associated with disease states, such as pneumonia, acute rejection and graft failure. In this review, we summarize the current understanding of the lung microbiome in lung transplant recipients, focusing on bacteria, but also highlighting key findings of the viral and the fungal community. Based on our knowledge of the lung microbiome in lung transplant recipients, we propose multiple opportunities for clinical use of the microbiome to improve outcomes in this population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text