Biopsy quality is essential for preoperative prognostication in oral tongue cancer

Autor: Pentti Nieminen, Alhadi Almangush, Ilmo Leivo, Maria Siponen, Ilida Suleymanova, Ahmed Qannam, Tuula Salo, Pia M. Wennerstrand, Ibrahim O. Bello
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
genetic structures
Biopsy
0302 clinical medicine
oral tongue cancer
Immunology and Allergy
Child
Finland
Aged
80 and over
medicine.diagnostic_test
General Medicine
Middle Aged
Prognosis
3. Good health
Tongue Neoplasms
medicine.anatomical_structure
Depth of invasion
030220 oncology & carcinogenesis
Preoperative Period
Female
Radiology
psychological phenomena and processes
Invasion front
Microbiology (medical)
Adult
medicine.medical_specialty
Incisional biopsy
quality of biopsy
Adolescent
Saudi Arabia
preoperative
behavioral disciplines and activities
Pathology and Forensic Medicine
03 medical and health sciences
Young Adult
Tongue
medicine
Humans
Neoplasm Invasiveness
Tumor stroma
Aged
business.industry
Squamous Cell Carcinoma of Head and Neck
Cancer
medicine.disease
030104 developmental biology
nervous system
Digital image analysis
prognosis
business
Zdroj: APMIS : acta pathologica, microbiologica, et immunologica ScandinavicaReferences. 129(3)
ISSN: 1600-0463
Popis: Background: A role for incisional biopsy in preoperative prognostication is increasingly being advocated in oral tongue squamous cell carcinomas (OTSCC). Biopsies at two locations were compared and prognostic factors in biopsies and their corresponding resections were evaluated. Methods: A total of 138 OTSCC biopsy slides from Finland and Saudi-Arabia were compared for size (horizontal and vertical) and invasive front. The Finnish cases were assessed for tumor stroma ratio (TSR) and tumor-infiltrating lymphocytes (TILs) using light microscopy and digital image analysis assessment and compared. Furthermore, TSR, TILs, and previously analyzed budding and depth of invasion (BD) score in biopsies were compared with their evaluation in the corresponding resections. Results: Finnish biopsies were deeper than Saudi-Arabian biopsies (59% versus 42%) while Saudi-Arabian biopsies were wider (98% versus 76%). Invasion fronts were more readily assessable in Finnish biopsies (72% versus 40%). There was 86.8% agreement between TSR and 75% agreement between TIL evaluation using light microscopy and digital assessment. Significant agreement was obtained on comparing the TSR (P=0.04) and BD (P Conclusions: Biopsies of ≥5 mm depth from representative OTSCC areas are essential for prognostic information. Clinical pathologists are advised to assess BD score and TSR for prognostic features in such biopsies.
Databáze: OpenAIRE
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