Subgenotype analysis of Cryptosporidium parvum isolates from humans and animals in Japan using the 60-kDa glycoprotein gene sequences
| Autor: | Niichiro Abe, Isao Kimata, Motohiro Iseki, Makoto Matsubayashi |
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| Rok vydání: | 2006 |
| Předmět: |
Genotype
Cryptosporidium infection animal diseases Genes Protozoan Molecular Sequence Data Protozoan Proteins Cattle Diseases Cryptosporidiosis Intestinal parasite Biology medicine.disease_cause Apicomplexa Dogs Japan parasitic diseases medicine Animals Humans Parasite hosting Dog Diseases Gene Phylogeny Cryptosporidium parvum Membrane Glycoproteins Sequence Homology Amino Acid General Veterinary Genetic heterogeneity Sequence Analysis DNA General Medicine DNA Protozoan Raccoon Dogs medicine.disease biology.organism_classification Virology Infectious Diseases Insect Science Cattle Parasitology |
| Zdroj: | Parasitology Research. 99:303-305 |
| ISSN: | 1432-1955 0932-0113 |
| DOI: | 10.1007/s00436-006-0140-0 |
| Popis: | Cryptosporidium parvum is a well-known intestinal parasite which is associated with severe acute diarrhea in humans and animals. This parasite is composed of morphologically identical but genetically different multiple genotypes. In humans, cryptosporidiosis is mainly caused by two C. parvum genotypes, human genotype (previously known as genotype 1 and recently proposed as new species C. hominis) and cattle genotype (previously known as genotype 2). However, recent molecular studies indicate the genetic heterogeneity among the isolates of C. parvum human or cattle genotype. Therefore, identification of the isolates at the subgenotype level is more useful for control of the Cryptosporidium infection or for understanding of the population structure of C. parvum genotypes. In the present study, we identified the subgenotypes of the C. parvum human or cattle genotype isolates from humans and animals in Japan using DNA sequencing analysis of the C. parvum 60-kDa glycoprotein gene (GP60) and showed the new subgenotype in a raccoon dog isolate. This study suggested that C. parvum cattle genotype might be composed of zoonotic and host-specific multiple subgenotypes. |
| Databáze: | OpenAIRE |
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