Evaluation of mitochondrial respiratory chain in the brain of rats after pneumococcal meningitis
| Autor: | Daiane B. Fraga, Gisele Bellettini, Emilio L. Streck, Geovana D. Savi, Jaqueline S. Generoso, Gislaine T. Rezin, Giselli Scaini, Juliana F. Daufenbach, Lutiana R. Simões, Tatiana Barichello |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Central nervous system Hippocampus Context (language use) Biology medicine.disease_cause Electron Transport Internal medicine Streptococcus pneumoniae medicine Animals Rats Wistar Meningitis Pneumococcal General Neuroscience Brain medicine.disease Respiratory enzyme Mitochondria Rats Disease Models Animal Endocrinology medicine.anatomical_structure Mitochondrial respiratory chain Electron Transport Chain Complex Proteins Cerebral cortex Immunology Meningitis |
| Zdroj: | Brain Research Bulletin. 82:302-307 |
| ISSN: | 0361-9230 |
| Popis: | The brain is highly dependent on ATP and most cell energy is obtained through oxidative phosphorylation, a process requiring the action of various respiratory enzyme complexes located in a special structure of the inner mitochondrial membrane. Bacterial meningitis due to Streptococcus pneumoniae is associated with a significant mortality rate and persisting neurologic sequelae including sensory-motor deficits, seizures, and impairments of learning and memory. In this context, we evaluated the activities of mitochondrial respiratory chain complexes in the brain of rats submitted to meningitis by S. pneumoniae inoculation into the cisterna magna. Our results demonstrated that complex I activity was not altered in cerebral cortex after meningitis; complexes II, III and IV were increased 24 and 48 h after meningitis. We have also verified that complex I was inhibited in prefrontal cortex 48 h after meningitis; complexes II, III and IV were not altered. Our results also demonstrated that complex I activity was inhibited in striatum, hippocampus and cerebellum 24 h after meningitis. Moreover, complex II activity was increased in hippocampus and striatum 24 and 48 h after meningitis; complexes III and IV activity were increased in striatum, hippocampus and cerebellum 48 h after meningitis. Taking together previous reports and our present findings, we speculate that oxidative stress and metabolism impairment might contribute, at least in part, for the pathogenesis of pneumococcal meningitis. |
| Databáze: | OpenAIRE |
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