Impairment of immunity in children of growing age suffering from recurrent respiratory diseases
Autor: | O.V. Zhuravel, L.V. Stamboli, L.V. Slipachuk, T.V. Pochinok |
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Rok vydání: | 2019 |
Předmět: | |
Zdroj: | Sovremennaâ Pediatriâ, Iss 1(97), Pp 39-45 (2019) |
ISSN: | 2412-4508 1992-5913 |
DOI: | 10.15574/sp.2019.97.39 |
Popis: | Objective: to define the diagnostic value of immunological resistance parameters in children suffering from recurrent respiratory diseases, to analyse the microflora of mucous membranes of a mouth in this category of children. Materials and methods. 60 children at the age of 10–16 years with the recurrent respiratory diseases (RRD) were examined. All children were divided into two groups: the main group included 30 children with RRD (6–8 times per year), the control group included 30 children with 2–4 episodes of respiratory diseases per year. All children were examined for physical development by the method of сentilny standards, also, all-clinical methods researches were conducted; the analysis of the children and their parents given to the anamnesis was also, carried out. The microbiological research of material from the surface of mucous membrane of the oral cavity and a pharynx was conducted. The immunological check-up included indicators of peripheral blood neutrophils functional activity according to a phagocytosis and the NBT-test, the maintenance of circulating immune complexes (CIC), concentration of immunoglobulins of G, A, M and secretory immunoglobulin A (sIgA) classes and lysozyme, by radial immunodiffusion method, and concentration of interleukin-6 (IL-6) and interleukin-4 (IL-4) by ELISA method. Results. According to clinical and medical history data, children with RRD suffered from pharyngitis, laryngitis, tonsillitis much more often. Among children, with RRD, against the background of the increased identification of opportunistic flora, compared to control group, the inhibition of phagocytic activity of neutrophils was revealed, specifically, a significant decrease in the activity of phagocytosis and reduction of reserve capacity of neutrophils under conditions of their stimulation (р |
Databáze: | OpenAIRE |
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