Reliability of one-point blood sampling method for calculating input function in Na18F PET
| Autor: | Mikihiro Fujioka, Toshikazu Kubo, Fuminori Nakamura, Kenji Itani, Kazuo Wakita, Yoshio Imahori, Tsunehiko Nishimura, Tatsuo Ido, Tetsurou Hirata |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Fluorine Radioisotopes Coefficient of variation Sensitivity and Specificity Statistics Image Interpretation Computer-Assisted Humans Radiology Nuclear Medicine and imaging Time point Reference table Reliability (statistics) Mathematics Aged Aged 80 and over Sampling (statistics) Reproducibility of Results General Medicine Venous blood Middle Aged Image Enhancement Positron-Emission Tomography Sample Size Arterial blood Sodium Fluoride Female Bone Diseases Radiopharmaceuticals Algorithms Diagnostic Techniques Radioisotope Blood sampling |
| Zdroj: | Nuclear medicine communications. 26(6) |
| ISSN: | 0143-3636 |
| Popis: | Objective Conventional methods of quantitative Na 1 8 F positron emission tomography require multiple arterial blood sampling in order to obtain the input function, and the procedures are invasive and complicated. This study aims to establish a simplified and reliable technique for obtaining the input function. Methods Multiple arterial blood sampling was performed on 12 persons. The time point for one-point sampling was determined as the time when (1) the plasma radioactivity obtained showed the highest correlation to the real integrated value, which was calculated from the input function, and (2) the coefficient of variation of the real integrated value divided by plasma radioactivity obtained at each time point became the minimum. Scaling factors were obtained in order to estimate the plasma radioactivity at each time point, and a reference table was produced in order to estimate the input function. Results The optimal timing for one-point sampling was 12 min after intravenous injection of Na 1 8 F. The estimated integrated value obtained from arterial blood sampling at 12 min and the reference table was highly correlated with the real integrated value (P |
| Databáze: | OpenAIRE |
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