A Case Study: The Use of Cidofovir for the Management of Progressive Multifocal Leukoencephalopathy
| Autor: | Robert Thomas Dodge |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male medicine.medical_specialty Pediatrics Opportunistic infection viruses Organophosphonates Congenital cytomegalovirus infection JC virus medicine.disease_cause Antiviral Agents Drug Administration Schedule Cytosine chemistry.chemical_compound Organophosphorus Compounds Clinical Protocols medicine Paralysis Humans Longitudinal Studies Advanced and Specialized Nursing AIDS-Related Opportunistic Infections business.industry Progressive multifocal leukoencephalopathy Leukoencephalopathy Progressive Multifocal virus diseases medicine.disease Surgery Clinical trial Treatment Outcome Hemiparesis chemistry medicine.symptom business Cidofovir |
| Zdroj: | Journal of the Association of Nurses in AIDS Care. 10:70-74 |
| ISSN: | 1055-3290 |
| DOI: | 10.1016/s1055-3290(06)60311-7 |
| Popis: | Progressive Multifocal Leukoencephalopathy (PML) is an opportunistic infection of the brain in advanced stages of AIDS. PML is caused by the JC virus, which leads to a decline in mental acuity and motor functions over a period of weeks or months. Currently, there is no treatment or cure for PML. Cidofovir, an antiviral agent, at the standard dosages for the treatment of cytomegalovirus (CMV) was implemented in the treatment and management of a 35-year-old, newly diagnosed AIDS, White male with PML. The patient presented with impaired motor functions of the left upper and lower extremities, which resulted in hemiparalysis and hemiparesis. The use of cidofovir infusions at standard recommendations for treatment and management of CMV has resulted in improvement and some resolution of the patient's paralysis and paresthesia. The patient has remained on the cidofovir for more than a year, with no signs of advancement of his PML or AIDS. Further investigation and extensive clinical trials are needed in the treatment and management of PML with the use of cidofovir. |
| Databáze: | OpenAIRE |
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