The impact of Helicobacter pylori infection, eradication therapy and probiotic supplementation on gut microenvironment homeostasis: An open-label, randomized clinical trial
| Autor: | Wenli Xu, Lan Wang, Allen Lee, Sanchuan Lai, Bixia Huang, Jiamin He, Luyi Chen, Yujia Chen, Jianmin Si, Shujie Chen, Kan Wang, Yanqin Long, Wenfang Zheng, Hua Chu, Tingting Su |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Research paper Bismuth-containing quadruple therapy Gut microbiota Gut flora Group A Gastroenterology General Biochemistry Genetics and Molecular Biology Group B law.invention Helicobacter Infections 03 medical and health sciences Probiotic 0302 clinical medicine Immune system Randomized controlled trial law Internal medicine medicine Homeostasis Humans Disease Eradication Clostridium butyricum biology Helicobacter pylori business.industry Probiotics General Medicine biology.organism_classification bacterial infections and mycoses 3. Good health Gastrointestinal Microbiome 16S rRNA sequencing 030104 developmental biology Dietary Supplements 030211 gastroenterology & hepatology Female business Follow-Up Studies |
| Zdroj: | EBioMedicine |
| ISSN: | 2352-3964 |
| Popis: | Background Helicobacter pylori (H. pylori) infection is associated with remodeling of gastric microbiota. However, comprehensive analyses of the impact of H. pylori infection, eradication therapy and probiotic supplementation on gut microbiota are still lacking. We aimed to provide evidence for clinical decision making. Methods Seventy H. pylori-positive and 35 H. pylori-negative patients (group C) were enrolled. H. pylori-positive patients were randomly assigned to group A (14-day bismuth-containing quadruple therapy) and group B (quadruple therapy supplemented with Clostridium butyricum). Stool samples of group A and B were collected on day 0, 14 and 56 while stool samples of group C were collected on day 0. Gut microbiota was investigated by 16S rRNA sequencing. Findings The Sobs index (richness estimator) was significantly higher in H. pylori-positive samples than H. pylori-negative samples (p |
| Databáze: | OpenAIRE |
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