Epilepsy syndromes of childhood with sleep activation: Insights from functional imaging
| Autor: | Patrick Van Bogaert |
|---|---|
| Přispěvatelé: | Laboratoire Angevin de Recherche en Ingénierie des Systèmes (LARIS), Université d'Angers (UA) |
| Rok vydání: | 2019 |
| Předmět: |
[SDV]Life Sciences [q-bio]
Centrotemporal spikes 03 medical and health sciences Epilepsy 0302 clinical medicine Neuroimaging 030225 pediatrics Continuous spike waves during sleep medicine Humans Ictal Child Default mode network business.industry Functional Neuroimaging Neuropsychology Brain Cognition Functional cerebral imaging General Medicine medicine.disease Childhood 3. Good health Functional imaging Pediatrics Perinatology and Child Health Epilepsy syndromes Neurology (clinical) business Sleep Neuroscience Epileptic Syndromes 030217 neurology & neurosurgery |
| Zdroj: | European Journal of Paediatric Neurology European Journal of Paediatric Neurology, Elsevier, 2020, 24, pp.58-60. ⟨10.1016/j.ejpn.2019.12.006⟩ |
| ISSN: | 1532-2130 1090-3798 |
| DOI: | 10.1016/j.ejpn.2019.12.006⟩ |
| Popis: | International audience; In epilepsy syndromes of childhood with sleep activation, defined as the spectrum of epileptic conditions going from classical benign childhood epilepsy with centrotemporal spikes (BECTS) to epileptic encephalopathy (EE) with continuous spike and waves during slow-wave sleep (CSWS) including Landau-Kleffner syndrome (LKS), a lot of functional imaging studies have been performed so far, leading to results that are not always consistent, related to the technique of neuroimaging performed and to the variability of the clinical phenotype. Most consistent findings are, depending of the method used, activations or increased regional glucose metabolism in the epileptogenic regions, and deactivations, hypometabolism or decreased functional connectivity in cortical regions that belong to the default mode network. Functional changes are either transitory, temporally related to the occurrence of interictal epileptiform discharges (IED), or permanent, persisting across IED-free periods. Some studies have shown that the more severe phenotype, i.e. EE with CSWS, displays the more profound functional disturbances. Taken together, functional imaging studies support the concept that IED impact cognition in epilepsy syndromes of childhood with sleep activation. However, the precise chronology between the occurrence of IED and the functional disturbances, the neuropsychological correlates of the functional disturbances, and the effects of the anti-epileptic treatments on IED, functional disturbances and cognition need to be further studied.Copyright © 2019 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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