| Autor: |
Geehan Suleyman, Raef Fadel, Ayman Alsaadi, Luis Ng Sueng, Ali Ghandour, Ahmad Alkhatib, Tarandeep Singh, Austin Parsons, Joseph Miller, Mayur Ramesh, Indira Brar, George Alangaden |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Open Forum Infectious Diseases. 9 |
| ISSN: |
2328-8957 |
| DOI: |
10.1093/ofid/ofac213 |
| Popis: |
Background Characterization of disease progression and outcomes after coronavirus disease 2019 (COVID-19)–related hospitalization in vaccinated compared with unvaccinated individuals is limited. Methods This was a retrospective case–control study of symptomatic vaccinated (cases) and unvaccinated (controls) participants hospitalized for COVID-19 between December 30, 2020, and September 30, 2021, in Southeast Michigan. Hospitalized adult patients with lab-confirmed COVID-19 were identified through daily census report. Breakthrough infection was defined as detection of severe acute respiratory syndrome coronavirus 2 ≥14 days after completion of the primary vaccination series. The association between prior vaccination and critical COVID-19 illness (composite of intensive care unit [ICU] admission, invasive mechanical ventilation [IMV], 28-day mortality) was examined. Results Two hundred ten (39%) fully vaccinated and 325 (61%) unvaccinated patients were evaluated. Compared with controls, cases were older, had more comorbidities (4 [3–7] vs 2 [1–4]; P Conclusions COVID-19-vaccinated patients were less likely to develop critical COVID-19 illness and more likely to survive. Disease severity at presentation was a predictor of adverse outcomes regardless of vaccination status. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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