Deterioration of bone microstructure by aging and menopause in Japanese healthy women: analysis by HR-pQCT
| Autor: | Kazuaki Yokota, Mitsuru Doi, Choko Kondo, Makoto Era, Akihiko Yonekura, Ko Chiba, Yuichiro Nishino, Masato Tomita, Makoto Osaki, Narihiro Okazaki, Shuta Yamada |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
0301 basic medicine Aging Endocrinology Diabetes and Metabolism Finite Element Analysis 030209 endocrinology & metabolism Bone and Bones 03 medical and health sciences Absorptiometry Photon 0302 clinical medicine Endocrinology Asian People Japan Bone Density Cortical Bone medicine Humans Orthopedics and Sports Medicine Tibia Quantitative computed tomography Voxel size Aged Structure model index medicine.diagnostic_test business.industry General Medicine Middle Aged medicine.disease Microstructure Menopause Trabecular bone medicine.anatomical_structure Cancellous Bone Linear Models Female Cortical bone 030101 anatomy & morphology Tomography X-Ray Computed business Porosity Biomedical engineering |
| Zdroj: | Journal of Bone and Mineral Metabolism. 38:826-838 |
| ISSN: | 1435-5604 0914-8779 |
| DOI: | 10.1007/s00774-020-01115-z |
| Popis: | Second-generation high-resolution peripheral quantitative computed tomography (HR-pQCT) has provide higher quality of bone images with a voxel size of 61 µm, enabling direct measurements of trabecular thickness. In addition to the standard parameters, the non-metric trabecular parameters such as trabecular morphology (plate to rod-like structures), connectivity, and anisotropy can also be analyzed. The purpose of this study is to investigate deterioration of bone microstructure in healthy Japanese women by measuring standard and non-metric parameters using HR-pQCT. Study participants were 61 healthy Japanese women (31–70 years). The distal radius and tibia were scanned using second-generation HR-pQCT, and microstructures of trabecular and cortical bone were measured. Non-metric trabecular parameters included structure model index (SMI), trabecular bone pattern factor (TBPf), connectivity density (Conn.D), number of nodes (N.Nd/TV), degree of anisotropy (DA), and star volume of marrow space (V*ms). Estimated bone strength was evaluated by micro finite element analysis. Associations between bone microstructure, estimated bone strength, age, and menopause were analyzed. Trabecular number declined with age, and trabecular separation increased. SMI and TBPf increased, Conn.D and N.Nd/TV declined, and V*ms increased. Cortical BMD and thickness declined with age, and porosity increased. Stiffness and failure load decreased with age. Cortical thickness and estimated bone strength were affected by menopause. Cortical thickness was most associated with estimated bone strength. Trabecular and cortical bone microstructure were deteriorated markedly with age. Cortical thickness decreased after menopause and was most related to bone strength. Non-metric parameters give additional information about osteoporotic changes of trabecular bone. |
| Databáze: | OpenAIRE |
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