Predicting the Fine Particle Fraction of Dry Powder Inhalers Using Artificial Neural Networks
| Autor: | Darragh Murnane, Joanna Muddle, Jogoth Ali, Ben Forbes, Clive P. Page, Irene Parisini, Marc B. Brown, Andrew Muddle, Stewart B. Kirton |
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| Rok vydání: | 2016 |
| Předmět: |
Active ingredient
Multivariate statistics Principal Component Analysis Artificial neural network Inhaler Pharmaceutical Science Dry Powder Inhalers 02 engineering and technology 021001 nanoscience & nanotechnology 030226 pharmacology & pharmacy Dry-powder inhaler Bronchodilator Agents 03 medical and health sciences Taguchi methods 0302 clinical medicine Principal component analysis Albuterol Neural Networks Computer Orthogonal array Particle Size Powders 0210 nano-technology Biological system Salmeterol Xinafoate Mathematics |
| Zdroj: | Journal of pharmaceutical sciences. 106(1) |
| ISSN: | 1520-6017 |
| Popis: | Dry powder inhalers are increasingly popular for delivering drugs to the lungs for the treatment of respiratory diseases, but are complex products with multivariate performance determinants. Heuristic product development guided by in vitro aerosol performance testing is a costly and time-consuming process. This study investigated the feasibility of using artificial neural networks (ANNs) to predict fine particle fraction (FPF) based on formulation device variables. Thirty-one ANN architectures were evaluated for their ability to predict experimentally determined FPF for a self-consistent dataset containing salmeterol xinafoate and salbutamol sulfate dry powder inhalers (237 experimental observations). Principal component analysis was used to identify inputs that significantly affected FPF. Orthogonal arrays (OAs) were used to design ANN architectures, optimized using the Taguchi method. The primary OA ANN r2 values ranged between 0.46 and 0.90 and the secondary OA increased the r2 values (0.53-0.93). The optimum ANN (9-4-1 architecture, average r2 0.92 ± 0.02) included active pharmaceutical ingredient, formulation, and device inputs identified by principal component analysis, which reflected the recognized importance and interdependency of these factors for orally inhaled product performance. The Taguchi method was effective at identifying successful architecture with the potential for development as a useful generic inhaler ANN model, although this would require much larger datasets and more variable inputs. |
| Databáze: | OpenAIRE |
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