Longitudinal changes in glucocorticoid metabolism are associated with later development of adverse metabolic phenotype
| Autor: | Cedric H. L. Shackleton, Susan V. Hughes, Beverly A. Hughes, Peter Nightingale, Paul M. Stewart, Nicola Crabtree, Theresa McCarthy, Rachel K Crowley, Joanna Gray, Jeremy W. Tomlinson |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class Endocrinology Diabetes and Metabolism medicine.medical_treatment Blood Pressure Biology Endocrinology Insulin resistance 3-Oxo-5-alpha-Steroid 4-Dehydrogenase Predictive Value of Tests Mineralocorticoids Internal medicine Diabetes mellitus 11-beta-Hydroxysteroid Dehydrogenase Type 1 medicine Humans Insulin Longitudinal Studies Prospective Studies Glucocorticoids Aged Area under the curve General Medicine Middle Aged medicine.disease Obesity Phenotype Glucocorticoid secretion Mineralocorticoid Linear Models Female Insulin Resistance Glucocorticoid medicine.drug |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1479-683X 0804-4643 |
| Popis: | ObjectiveDysregulation of enzymes that control local tissue steroid metabolism has been implicated in the pathogenesis of obesity and insulin resistance; however, longitudinal changes in glucocorticoid metabolism have not been investigated. This study was performed to evaluate the role of glucocorticoid metabolism in the development of insulin resistance and obesity and to identify biomarkers for future development of metabolic disease.DesignThis was a prospective longitudinal observation study conducted over 5 years.MethodsA 24-h collection was used to serially analyze urinary glucocorticoid and mineralocorticoid metabolites in 57 obese and overweight patients with no prior diagnosis of diabetes mellitus, recruited from the community.ResultsBaseline higher 5α-reductase (5αR) activity, but not 11β-hydroxysteroid dehydrogenase type 1 activity, was predictive of increased fasting insulin at final visit (11.4 compared with 7.4 mU/l in subjects with lower 5αR activity, PPPConclusionsIncreased 5αR activity and glucocorticoid secretion rate over time are linked with the development of metabolic disease, and may represent targets for therapeutic intervention, which merits further study. |
| Databáze: | OpenAIRE |
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