Mechanisms of Sound-Induced Opening of the Blood-Brain Barrier
| Autor: | Valerii V Tuchin, Inna Blokhina, Yirong Yang, Ilana Agranovich, Olga A Bragina, Alexander Khorovodov, A. Esmat, Andrey Terskov, Alexander Shirokov, Oksana V. Semyachkina-Glushkovskaya, Maria Klimova, Nikita A. Navolokin, Juergen Kurths, Arkady S. Abdurashitov, Denis E. Bragin |
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| Rok vydání: | 2021 |
| Předmět: |
Sound (medical instrument)
business.industry Stress induced Drug delivery to the brain Brain Biological Transport Blood–brain barrier Article Rats Clinical Practice 03 medical and health sciences Drug Delivery Systems Sound 0302 clinical medicine medicine.anatomical_structure nervous system Blood-Brain Barrier Drug delivery cardiovascular system medicine Animals 030212 general & internal medicine business Neuroscience |
| Zdroj: | Advances in Experimental Medicine and Biology ISBN: 9783030482367 Adv Exp Med Biol |
| DOI: | 10.1007/978-3-030-48238-1_31 |
| Popis: | The blood-brain barrier (BBB) poses a significant challenge for drug delivery to the brain. The limitations of our knowledge about the nature of BBB explains the slow progress in the therapy of brain diseases and absence of methods for drug delivery to the brain in clinical practice. Here we show that the BBB opens for high molecular weight compounds after exposure to loud sound (100 dB 370 Hz) in rats. The role of stress induced by loud sound and the systemic and molecular mechanisms behind it are discussed in the framework of the BBB opening as an informative platform for a novel fundamental knowledge about the nature of BBB and for the development of a non-invasive brain drug delivery technology. |
| Databáze: | OpenAIRE |
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