Selective extraction of piceatannol from Passiflora edulis by-products: application of HSPs strategy and inhibition of neurodegenerative enzymes
| Autor: | Elena Ibáñez, Alejandro Cifuentes, Juliane Viganó, Julian Martínez, Jose A. Mendiola, A. P. Sánchez-Camargo, Gerardo Álvarez-Rivera, Luana Cristina dos Santos |
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| Přispěvatelé: | Fundação de Amparo à Pesquisa do Estado de São Paulo, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil), Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
QH301-705.5 Lipoxygenase Ethyl acetate Hansen solubility parameters Catalysis Article Inorganic Chemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Lipoxygenase Inhibitors Physical and Theoretical Chemistry Biology (General) Molecular Biology QD1-999 Spectroscopy Piceatannol Chromatography Ethanol biology Passiflora Plant Extracts Organic Chemistry Extraction (chemistry) Neurodegenerative Diseases General Medicine Computer Science Applications Passion fruit by-products Solvent Chemistry 030104 developmental biology chemistry Benzyl alcohol Polyphenol Fruit Pressurized liquid extraction Seeds biology.protein Solvents Acetylcholinesterase Cholinesterase Inhibitors 030217 neurology & neurosurgery |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 6248, p 6248 (2021) Digital.CSIC. Repositorio Institucional del CSIC instname International Journal of Molecular Sciences Volume 22 Issue 12 |
| Popis: | This article belongs to the Special Issue Advances on the Neuroprotective Effect of Food and Natural Bioactive Compounds on Alzheimer 2.0. Passiflora edulis by-products (PFBP) are a rich source of polyphenols, of which piceatannol has gained special attention recently. However, there are few studies involving environmentally safe methods for obtaining extracts rich in piceatannol. This work aimed to concentrate piceatannol from defatted PFBP (d-PFBP) by means of pressurized liquid extraction (PLE) and conventional extraction, using the bio-based solvents selected with the Hansen solubility parameters approach. The relative energy distance (Ra) between solvent and solute was: Benzyl Alcohol (BnOH) < Ethyl Acetate (EtOAc) < Ethanol (EtOH) < EtOH:H2O. Nonetheless, EtOH presented the best selectivity for piceatannol. Multi-cycle PLE at 110 °C was able to concentrate piceatannol 2.4 times more than conventional extraction. PLE exhibited a dependence on kinetic parameters and temperature, which could be associated with hydrogen bonding forces and the dielectric constant of the solvents. The acetylcholinesterase (AChE) and lipoxygenase (LOX) IC50 were 29.420 μg/mL and 27.682 μg/mL, respectively. The results reinforce the demand for processes to concentrate natural extracts from food by-products. his work was supported by the São Paulo Research Foundation (FAPESP) Process number 2017/11245-5, 2019/10655-0, and 2017/23670-2, CNPq (303063/2018-1 and 408285/2018-4), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES)—Finance Code 001, and the Spanish Ministry of Science and Innovation (project AGL2017-89417-R). |
| Databáze: | OpenAIRE |
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