Characterization of the Venom of C. d. cumanesis of Colombia: Proteomic Analysis and Antivenomic Study
| Autor: | Leidy J. Vargas, Juan Carlos Quintana-Castillo, Juan C. Alarcón, Cesar Segura, Sebastián Estrada-Gómez, Julio César Bueno-Sánchez |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Proteomics Health Toxicology and Mutagenesis Antivenom Zoology lcsh:Medicine Venom Reptilian Proteins Colombia Toxicology Article Myasthenic facies 03 medical and health sciences Crotalid Venoms C. d. cumanensis venom antivenom HPLC-nESI-MS/MS peptide identification Key ContributionThis work carried out a proteomic analysis of C. d. cumanensis from Colombia by using HPLC-nESI MS/MS and subsequently was evaluated the effect of a commercial antivenom against the venom Paralysis medicine Animals Key Contribution biology Antivenins lcsh:R Crotalus Péptidos biology.organism_classification Crotamine 030104 developmental biology Snake venom Venenos de Serpiente Neurotoxic effect medicine.symptom Peptides Snake Venoms |
| Zdroj: | Toxins Repositorio UdeA Universidad de Antioquia instacron:Universidad de Antioquia Toxins, Vol 10, Iss 2, p 85 (2018) Toxins; Volume 10; Issue 2; Pages: 85 |
| ISSN: | 2072-6651 |
| Popis: | The Colombian rattlesnake Crotalus durissus cumanensis is distributed in three geographic zones of the country: the Atlantic Coast, the upper valley of the Magdalena River, and the eastern plains of the Colombian Orinoquía. Its venom induces neurological symptoms, such as eyelid ptosis, myasthenic facies, and paralysis of the respiratory muscles, which can lead to death. Identification and analysis of C. d. cumanensis showed nine groups of proteins responsible for the neurotoxic effect, of which the crotoxin complex was the most abundant (64.71%). Immunorecognition tests of C. d. cumanensis showed that the use of a commercial antivenom manufactured in Mexico resulted in immunoreactivity. COL0007631 COL0007524 COL0014476 |
| Databáze: | OpenAIRE |
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