Factors influencing ultrasonographic remission in patients with rheumatoid arthritis
| Autor: | İbrahim Tekeoğlu, Nedim Kaban, Sibel Harman, Halil Harman |
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| Přispěvatelé: | Harman, H, Tekeoglu, I, Kaban, N, Harman, S, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Harman, Halil, Tekeoğlu, İbrahim, Kaban, Nedim |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Delayed Diagnosis Time Factors Hand Joints Immunology Arthritis Severity of Illness Index Gastroenterology Etanercept Arthritis Rheumatoid Cohort Studies Rheumatology Adrenal Cortex Hormones Internal medicine Synovitis Severity of illness medicine Humans Immunology and Allergy Subclinical infection Leflunomide Tenosynovitis business.industry Anti-Inflammatory Agents Non-Steroidal Remission Induction Adalimumab Ultrasonography Doppler Isoxazoles Middle Aged medicine.disease Surgery Sulfasalazine Logistic Models Methotrexate Antirheumatic Agents Rheumatoid arthritis Multivariate Analysis Female Rituximab business medicine.drug |
| Zdroj: | Rheumatology International. 35:485-491 |
| ISSN: | 1437-160X 0172-8172 |
| DOI: | 10.1007/s00296-014-3177-x |
| Popis: | The aim of this study was to define the ultrasonographic factors that indicate clinical remission in patients with RA. We enrolled a cohort of patients with RA in whom the disease had been in remission for at least 6 months. Musculoskeletal ultrasound (US) examination was used to evaluate the status of active synovitis, power Doppler (PD) signalling, and synovitis in the bilateral metacarpophalangeal; proximal interphalangeal; and radiocarpal, ulnocarpal, and intercarpal, compartments of the wrist. A total of 64 RA patients with a mean disease duration of 79.97 months were studied. Of all patients, 36 % had ultrasonographic synovitis and 29 % an increased PD signal from at least one joint. Delay in diagnosis was highly correlated with synovitis and PD synovitis (r = 0.55, p = 0.000; and r = 0.51, p = 0.001, respectively). A weak negative correlation was evident between synovitis, PD synovitis, tenosynovitis, PD tenosynovitis, and duration of clinical remission (respectively, r = -0.426, p = 0.000; r = -0.333, p = 0.007; r = -0.243, p = 0.050; and r = -0.247, p = 0.049). Upon multivariate logistic regression analysis, the duration of clinical remission and delay in diagnosis were the factors that most influenced ultrasonographic remission (OR 3.46, p = 0.046; OR 3.27, p = 0.016, respectively). Synovial inflammation may persist in RA patients exhibiting clinical remission. We found that US detected subclinical synovitis. The most important factors preventing ultrasonographic remission were a short duration of clinical remission and delay in diagnosis. |
| Databáze: | OpenAIRE |
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