Evaluation of the Gastroprotective Effect of the Flavonoid Complex from Lychnis chalcedonica L. on the Models of Experimental Ulcerogenesis
| Autor: | O. Yu. Rybalkina, L. N. Zibareva, O. G. Afanas’eva, S. G. Krylova, G. N. Zyuz’kov, T. N. Povet’eva, E. P. Zueva, N. I. Suslov, Yu. V. Nesterova |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification biology Traditional medicine Lychnis chalcedonica Flavonoid флавоноиды General Medicine ульцерогенез Reference drug biology.organism_classification General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure chemistry Eleutherococcus Gastric mucosa medicine Лихнис халцедонский гастропротекторный эффект Plantaglucide 030217 neurology & neurosurgery |
| Zdroj: | Bulletin of experimental biology and medicine. 2021. Vol. 171, № 2. P. 212-217 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-021-05197-1 |
| Popis: | Using rat and mouse models of neurogenic, ethanol-induced, and indometacin-induced damage to the gastric mucosa we demonstrated that course preventive treatment with flavonoid complex from aerial parts of Lychnis chalcedonica L. increased the resistance of gastric mucosa to ulcerogenic factors of different etiology. The gastroprotective effect of the phytocomplex in a dose range of 16-1600 μg/kg was comparable with that of the reference drug plantaglucide and was superior to that of the reference drugs eleutherococcus extract and methyluracil in the therapeutic doses. The antiulcerogenic activity of Lychnis chalcedonica flavonoid complex considerably exceeded activity of Lychnis chalcedonica L. extract demonstrated in our previous experiments. |
| Databáze: | OpenAIRE |
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