Thrazarine, a new antitumor antibiotic. II. Physico-chemical properties and structure determination
| Autor: | Hikaru Nakamura, Tomio Takeuchi, Toshiyuki Kameyama, Yoichi Iitaka, Yoshiro Okami, Daishiro Ikeda, Hiroshi Naganawa, Atsushi Takahashi, Shogo Kurasawa |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Pharmacology
Antibiotics Antineoplastic Chemical Phenomena medicine.drug_class Chemistry Antibiotics Absolute configuration Hydroxybutyrates Absolute structure chemistry.chemical_compound X-Ray Diffraction Ninhydrin Drug Discovery Serine medicine Organic chemistry Molecule Azaserine Acid hydrolysis Thrazarine medicine.drug |
| Zdroj: | The Journal of Antibiotics. 41:1568-1574 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.7164/antibiotics.41.1568 |
| Popis: | A new antitumor antibiotic thrazarine was soluble in water and positive to anisaldehyde-sulfuric acid and ninhydrin color reactions. The absolute structure of thrazarine was determined to be O-[3R)-2-diazo-3-hydroxybutyryl)-L-serine by acid hydrolysis, spectroscopic analysis and X-ray crystallographic analysis. Structurally, thrazarine was a new member of azaserine group antibiotics. |
| Databáze: | OpenAIRE |
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