Neuroprotective effect of retro-inverso Prosaptide D5 on focal cerebral ischemia in rat
| Autor: | J. S. O'brien, D. A. C. Otero, Ai Gang Lu, M. Hiraiwa |
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| Rok vydání: | 2000 |
| Předmět: |
Male
Molecular Sequence Data Ischemia Brain Edema Pharmacology Neuroprotection Brain Ischemia Rats Sprague-Dawley Neurotrophic factors In vivo Occlusion medicine Animals Amino Acid Sequence Nerve Growth Factors Stroke Prosaposin business.industry General Neuroscience Cerebral Infarction medicine.disease In vitro Rats Neuroprotective Agents Anesthesia business |
| Zdroj: | Neuroreport. 11(8) |
| ISSN: | 0959-4965 |
| Popis: | Prosaposin (the precursor of saposins A-D) has been identified as a neurotrophic factor in vitro and in vivo. In this study, a novel 11-mer retro-inverso peptidomimetic, Prosaptide D5, was injected i.m. to assess its effectiveness in a rat ischemic model produced by reversible total occlusion of the left middle cerebral artery (MCA). Prosaptide (300 microg/kg, i.m.) injected 3 h after reversible occlusion reduced brain infarct area by 56% compared with a saline group (p < 0.01) at 21 h of reperfusion. A similar injection of D5 6h after occlusion produced a 32% decrease. |
| Databáze: | OpenAIRE |
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