The effect of exchange transfusion on endogenous carbon monoxide production in erythroblastotic infants
| Autor: | Nicholas M. Nelson, Ambadas Pathak, M. Jeffrey Maisels |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
Chromatography
Gas Reticulocytes Bilirubin medicine.medical_treatment Exchange Transfusion Whole Blood Physiology Exchange transfusion Gestational Age Endogeny Serum bilirubin Erythroblastosis Fetal Hemoglobins chemistry.chemical_compound Pregnancy Humans Medicine Heme Erythroblastosis fetalis Hyperbilirubinemia Carbon Monoxide business.industry Body Weight Infant Newborn chemistry Anesthesia Pediatrics Perinatology and Child Health Female business Carbon monoxide |
| Zdroj: | The Journal of Pediatrics. 81:705-709 |
| ISSN: | 0022-3476 |
| DOI: | 10.1016/s0022-3476(72)80089-1 |
| Popis: | In order to elucidate the mechanism of the “late” postexchange transfusion bilirubin rebound, we measured endogenous carbon monoxide production in infants with erythroblastosis fetalis before and after exchange transfusions. The rate of carbon monoxide production was markedly increased before the first exchange transfusion and remained elevated until two, or in one case until three, exchange transfusions had been completed. Normal rates of carbon monoxide production were found when falling levels of serum bilirubin concentration indicated that further exchange transfusions were not necessary. These findings suggest that a continued increase in heme turnover is largely responsible for the “late” bilirubin rebound which occurs after exchange transfusions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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