Comparative study of three vaginal markers of the premature rupture of membranes. Insulin like growth factor binding protein 1 diamine-oxidase pH
| Autor: | René-Charles Rudigoz, Pascal Gaucherand, Bruno Salle, Jocelyne Brun, Suzanne Guibaud, Charles Albert Bizollon, Philippe Sergeant |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
medicine.medical_specialty
Fetal Membranes Premature Rupture Group A Group B Insulin-like growth factor-binding protein Sampling Studies Andrology Pregnancy Internal medicine Medicine Humans IGFBP1 biology business.industry Amine oxidase (copper-containing) Obstetrics and Gynecology General Medicine Hydrogen-Ion Concentration medicine.disease Insulin-Like Growth Factor Binding Protein 1 Endocrinology Membrane biology.protein Female Amine Oxidase (Copper-Containing) Diamine oxidase business Premature rupture of membranes |
| Zdroj: | Acta obstetricia et gynecologica Scandinavica. 76(6) |
| ISSN: | 0001-6349 |
| Popis: | To assess the diagnostic value of three vaginal markers-insulin-like growth factor binding protein 1 (= IGFBP1), diamine-oxidase (= DAO) and pH-for diagnosis of the premature rupture of membranes.One hundred pregnant women participated in the study. They were divided into three groups: group A (34 cases with intact membranes), group B (35 cases with total rupture of the membranes), group C (31 cases of suspected rupture of the membranes). Each patient underwent three successive tests for each of the three markers. The test order was allocated at random. For pH the reaction is colorimetric, for DAO the reaction is radio-enzymatic and for IGFBP1 the reaction is immuno-chromatographic. All three reactions are qualitative in nature. The parameters studied were conventional statistical parameters (sensitivity = SN, specificity = SP, positive predictive value = PPV and negative predictive value = NPV).The analysis of the statistics gave the following results in percentages for SN, SP, PPV and NPV respectively; pH: 90.7%, 77.2%, 75%, 91.7%. DAO: 83.7%, 100%, 100%, 89%. IGFBP1: 95.3%, 98.2%, 97.6%, 96.5%.The determination of variations in pH is not satisfactory. IGFBP1 is at least better than DAO with, additionally, advantages of rapidity and simplicity. |
| Databáze: | OpenAIRE |
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