Thymoquinone, the Nigella sativa Bioactive Compound, Prevents Circulatory Oxidative Stress Caused by 1,2-Dimethylhydrazine in Erythrocyte during Colon Postinitiation Carcinogenesis
| Autor: | Aya Maaloul, Mohamed Hammami, Touhami Mahjoub, Hanene Jrah Harzallah, Rahma Grayaa, Wafa Kharoubi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
Aging endocrine system Erythrocytes Article Subject Nigella sativa Pharmacology medicine.disease_cause Biochemistry Lipid peroxidation Superoxide dismutase chemistry.chemical_compound Hemoglobins Malondialdehyde medicine Benzoquinones Animals lcsh:QH573-671 Rats Wistar Thymoquinone chemistry.chemical_classification Glutathione Peroxidase biology lcsh:Cytology Superoxide Dismutase Glutathione peroxidase Cell Biology General Medicine Catalase 1 2-Dimethylhydrazine Rats Oxidative Stress Cell Transformation Neoplastic chemistry Hematocrit Colonic Neoplasms biology.protein Lipid Peroxidation Oxidative stress Research Article |
| Zdroj: | Oxidative Medicine and Cellular Longevity Oxidative Medicine and Cellular Longevity, Vol 2012 (2012) |
| ISSN: | 1942-0994 1942-0900 |
| Popis: | We have performed this study to investigate the modulatory effect of thymoquinone (TQ), theNigella sativaactive compound, on erythrocyte lipid peroxidation and antioxidant status during 1,2-dimethylhydrazine- (DMH-) induced colon carcinogenesis after initiation in male Wistar rats. Rats exposed to DMH showed an increase of malondialdehyde and conjugated diene levels, and an augmentation of enzyme activities like catalase, glutathione peroxidase, and superoxide dismutase activities was also noted. The TQ pretreatment restored the parameters cited above to near-normal values. However, the posttreatment shows an activity similar as that presented by DMH. Therefore, our investigation revealed that TQ was a useful compound preventing DMH-induced erythrocyte damages. |
| Databáze: | OpenAIRE |
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