Surgical Management of Pelvic Malignancy: Role of Extended Abdominoperineal Resection/Exenteration/Abdominal Sacral Resection
| Autor: | Harold J. Wanebo, Kimberly A. Varker, Giovanni Begossi |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
Sacrum medicine.medical_specialty Colorectal cancer Disease Carcinoembryonic antigen Risk Factors Adjuvant therapy Humans Medicine Neoplasm Invasiveness Stage (cooking) Digestive System Surgical Procedures biology Rectal Neoplasms Abdominoperineal resection business.industry Dissection Incidence (epidemiology) Anastomosis Surgical Laminectomy Surgical Mesh Prognosis medicine.disease Survival Analysis Carcinoembryonic Antigen Pelvic Exenteration Surgery Oncology Positron-Emission Tomography Localized disease Colonic Neoplasms biology.protein Female Stents Neoplasm Recurrence Local business |
| Zdroj: | Surgical Oncology Clinics of North America. 14:197-224 |
| ISSN: | 1055-3207 |
| Popis: | Although the incidence of locoregional recurrence of colorectal cancer after primary resection has been reduced by improved surgical techniques and the frequent use of neoadjuvant or adjuvant therapy, local failure remains a significant clinical problem. At diagnosis, 37% of patients with colorectal cancer have localized disease (5-year survival, 91%), 37% have regional disease (5-year survival, 66%), 20% have distant metastases (5-year survival, 8.5%), and 6% are unstaged [1,2]. Stage for stage, the outcome is worse for rectal cancer (5-year survival approximately 20% less) than for colon cancer. The primary determinants of survival are TNM stage and completeness of resection, with the goal being R0 resection (no gross or microscopic residual disease). Other prognostic factors include histologic type and grade, serum carcinoembryonic antigen (CEA) level, and extramural or submucosal |
| Databáze: | OpenAIRE |
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