Exercise Intervention in Pediatric Patients with Solid Tumors
Autor: | Carmen Fiuza-Luces, Rosalía Lorenzo-González, Antonio Pérez-Martínez, Alejandro Santos-Lozano, Margarita Pérez, Fabian Sanchis-Gomar, Helios Pareja-Galeano, Luisa Soares-Miranda, Julio R. Padilla, Elena Santana-Sosa, Alvaro Lassaletta, Zoraida Verde, Luis M. López-Mojares, Alejandro Lucia, Jaime Valentín Quiroga, Steven J. Fleck |
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Rok vydání: | 2017 |
Předmět: |
Male
Gerontology medicine.medical_specialty Ejercicio - Condicion Fisica medicine.medical_treatment Physical Therapy Sports Therapy and Rehabilitation Body Mass Index law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial Quality of life law Neoplasms Internal medicine Accelerometry Activities of Daily Living medicine Humans Orthopedics and Sports Medicine Muscle Strength Child Neoadjuvant therapy Exercise Tolerance Exercise intervention business.industry Pediatría Cancer Resistance Training Cardiorespiratory fitness 030229 sport sciences Cáncer Deporte medicine.disease Pediatric cancer Neoadjuvant Therapy Exercise Therapy Cardiorespiratory Fitness 030220 oncology & carcinogenesis Quality of Life Patient Compliance Female business Body mass index |
Zdroj: | ABACUS. Repositorio de Producción Científica Universidad Europea (UEM) |
ISSN: | 0195-9131 |
Popis: | The randomized controlled trial ‘Physical Activity in Pediatric Cancer’ (PAPEC) determined the effects of an in-hospital exercise intervention combining aerobic and muscle strength training on pediatric cancer patients with solid tumors undergoing neoadjuvant chemotherapy. Methods. Participants were allocated to an exercise (n=24, 17 boys; mean±SEM age 10±1y) or control group (n=25, 18 boys; 11±1y). Training included three sessions/week for 19±2 weeks. Participants were assessed at treatment initiation, termination, and two months after end-treatment. The primary endpoint was muscle strength (as assessed by upper and lower-body five-repetition-maximum (5RM) tests). Secondary endpoints included cardiorespiratory fitness, functional capacity during daily life activities, physical activity, body mass and body mass index, and quality of life. Results. Most sessions were performed in the hospital’s gymnasium. Adherence to the program averaged 68±4% and no major adverse events or health issues were noted. A significant interaction (group*time) effect was found for all 5RM tests. Performance significantly increased after training (leg press: 40% (95% CI=15–41 kg); bench press: 24% (95% CI=6–14 kg); lateral row 25% (95%CI=6–15 kg)), whereas an opposite trend was found in controls. Two-month post values tended to be higher than baseline for leg (P=0.017) and bench press (P=0.014). In contrast, no significant interaction effect was found for any of the secondary endpoints. Conclusion. An in-hospital exercise program for pediatric cancer patients with solid tumors undergoing neoadjuvant treatment increases muscle strength despite the aggressiveness of such therapy. Key words: Cancer, exercise, muscle strength, fitness, quality of life. Cátedra Real Madrid-Universidad Europea (2015/UEM07) and Fondo de Investigaciones Sanitarias and Fondos Feder (FIS, grant #PI12/00914). 4.291 JCR (2017) Q1, 7/81 Sport Sciences 2.073 SJR (2017) Q1, 10/285 Orthopedics and Sports Medicine, 5/201 Physical Therapy, Sports Therapy and Rehabilitation, 7/127 Sports Science No data IDR 2017 UEM |
Databáze: | OpenAIRE |
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