Dural non-Hodgkin’s lymphomas

Autor: E E Leenman, L G Babicheva, N. V. Ilyin, V V Ryabchikova, Irina V. Poddubnaya, Yu. N. Vinogradova, V. V. Baikov
Rok vydání: 2016
Předmět:
Zdroj: Современная онкология, Vol 18, Iss 2, Pp 19-26 (2016)
ISSN: 1815-1434
DOI: 10.26442/1815-1434_2016.2.19-26
Popis: Primary presentation of intradural non-Hodgkin lymphoma (PDL) is rare. Most published cases of PDL are single-patient reports. This lesion occurs more often in middle-aged women, in contrast to brain parenchyma primary central nervous system lymphoma (PCNSL), which has a slight male predilection. In contrast with parenchymal PCNSL, there has been no clear association between acquired and congenital immunosuppression and the development of PDL. The pathogenesis of PDL is not well understood because the dura is devoid of any lymphoid tissue. One hypothesis is that a benign inflammatory condition of the dura could attract polyclonal lymphocytes from which a monoclonal lymphoma could arise. B-cell lymphomas of mucosa-associated lymphoid tissue (MALT) have been recognized as an important pathologic subtype. A PDL is more indolent and has a better prognosis than parenchymal PCNSL or systemic lymphoma with CNS metastasis. However, further studies with longer clinical follow up are necessary to assess the final outcome in these patients. In general, patients with marginal zone lymphoma have a favorable outcome, with a 5-year overall survival rate greater than 86%, without significant differences between gastrointestinal and nongastrointestinal and between localized and disseminated disease.
Databáze: OpenAIRE
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