Melatonin receptor 1A gene polymorphism rs13140012 and serum melatonin in atherosclerotic versus non-atherosclerotic Egyptian ESRD patients: pilot study
| Autor: | Mohamed Hesham El Nashar, Eman Tayae Elsayed, Tarek Salem, Aliaa Aly El Aghoury, Noha Mohamed El Kholy |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty rs13140012 medicine.medical_treatment Gastroenterology Article Clinical research Melatonin 03 medical and health sciences 0302 clinical medicine Endocrinology Single nucleotide polymorphism (SNP) Cell surface receptor Internal medicine medicine SNP lcsh:Social sciences (General) lcsh:Science (General) Diagnostics Hemodialysis (HD) Renal system Multidisciplinary business.industry Health sciences Carotid intima-media thickness (CIMT) Atherosclerosis End-stage renal disease (ESRD) 030104 developmental biology Melatonin receptor 1A lcsh:H1-99 Gene polymorphism Hemodialysis business 030217 neurology & neurosurgery Biomedical sciences medicine.drug lcsh:Q1-390 |
| Zdroj: | Heliyon, Vol 6, Iss 7, Pp e04394-(2020) Heliyon |
| ISSN: | 2405-8440 |
| Popis: | Aim To study the relationship between melatonin levels and Melatonin membrane receptor 1A (MTNR1A) SNP (rs13140012) in end-stage renal disease patients (ESRD) in Alexandria, Egypt on maintenance hemodialysis with or without atherosclerosis. Materials and methods 40 end-stage renal disease patients on regular hemodialysis were divided into 2 subgroups, one with (n = 20) and one without atherosclerosis (n = 20) and normal subjects (n = 40). Serum melatonin, carotid intimal medial thickness (CIMT) were measured. Melatonin membrane receptor 1A (MTNR1A) SNP (rs13140012) genotyping was done using 5'nuclease Allelic discrimination. Results Serum melatonin was significantly lower in ESRD patients [1.6 to 11.30 (pg/mL) with a median of 2.5] than the control group [20.50 to 56.40 (pg/mL) with a median of 35.20]. Serum melatonin was significantly lower in atherosclerotic patients subgroup [1.6–2.50 (pg/mL) with a median value of 2.30] than non-atherosclerotic patients subgroup [2.0–11.30 (pg/mL) with a median of 4.9]. No significant association was found between serum melatonin and (MTNR1A) SNP (rs13140012) (p = 0.633). Conclusion These results lead us to suggest that melatonin production is impaired in ESRD patients (included in this pilot study), and this impairment is more evident in atherosclerotic ESRD patients. Health sciences; Renal system; Internal medicine; Endocrinology; Clinical research; Diagnostics; Melatonin; Single nucleotide polymorphism (SNP); rs13140012; Atherosclerosis; End-stage renal disease (ESRD); Hemodialysis (HD); Carotid intima-media thickness (CIMT) |
| Databáze: | OpenAIRE |
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