Novel Aza‐Michael Addition‐Asymmetric Protonation to α,β‐Unsaturated Carboxylic Acids with Chiral Thiourea‐Boronic Acid Hybrid Catalysts
| Autor: | Ayano Yamada, Hiroki Murakami, Kenichi Michigami, Yoshiji Takemoto |
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| Rok vydání: | 2021 |
| Předmět: |
inorganic chemicals
α β-unsaturated carboxylic acid organic chemicals Organic Chemistry Total synthesis Protonation Medicinal chemistry Catalysis chemistry.chemical_compound Thiourea chemistry Michael reaction asymmetric protonation heterocyclic compounds aza-Michael addition β²-amino acid total synthesis Boronic acid |
| Zdroj: | Asian Journal of Organic Chemistry. 10:1097-1101 |
| ISSN: | 2193-5815 2193-5807 |
| DOI: | 10.1002/ajoc.202100145 |
| Popis: | Novel aza-michael addition-asymmetric protonation to unsaturated carboxylic acids with chiral thiourea-boronic acid hybrid catalysts. #asymmetric protonationIn this study, an efficient method has been developed for controlling carbonyl α-chirality with functionalizing β-position by the conjugate addition-asymmetric protonation (CAAP) of α, β-unsaturated carboxylic acids using chiral thiourea-amino boronic acid hybrid catalysts. In addition, the method is applied to the asymmetric synthesis of biologically active compounds. |
| Databáze: | OpenAIRE |
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