Osteocalcin gene polymorphism and bone density in Hungarian athletes
| Autor: | István Györe, Márta Szmodis, Anna Protzner, Edit Bosnyák, Miklós Tóth, Zsolt Komka, Emese Trájer |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
0301 basic medicine medicine.medical_specialty Bone density Osteocalcin Osteoporosis Population Young Adult 03 medical and health sciences 0302 clinical medicine Bone Density Polymorphism (computer science) Internal medicine Genotype medicine Humans education Ecology Evolution Behavior and Systematics Bone mineral Hungary education.field_of_study Polymorphism Genetic biology business.industry General Medicine Middle Aged medicine.disease Genotype frequency 030104 developmental biology Endocrinology Athletes Case-Control Studies 030220 oncology & carcinogenesis Anthropology biology.protein Animal Science and Zoology business |
| Zdroj: | Anthropologischer Anzeiger. 73:155-159 |
| ISSN: | 0003-5548 |
| Popis: | SUMMARY Osteoporosis, a public health problem, is mainly determined on the basis of bone mineral density (BMD). The rs1800247 polymorphism of the osteocalcin gene is associated with BMD. The results of one recent Polish study led us to the examination of a possible connection between polymorphism and bone ultrasound parameters in the Hungarian population, including elite athletes. A total of 302 subjects participated in the study. Genotype analysis was carried out via a DNA chip, and anthropometric measurements were taken according to the International Biological Program. Sixty-three (63) of the participants were also measured by ultrasound bone densitometer. The genotype frequencies of osteocalcin polymorphism in the total sample were: 59.9% for hh; 36.1% for Hh; and 3.97% for HH. We separated the 63 subjects by the presence or absence of H allele, and there were no significant differences between the two groups, either in the anthropometric, or in the ultrasound parameters. In grouping the sample by genotypes, no differences were detectable in any of the bone characteristics. Compared to the controls, athletes had significantly higher results in all of the bone ultrasound values. The polymorphism of the osteocalcin gene showed no effect on bone quantity in the examined Hungarian population. |
| Databáze: | OpenAIRE |
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