Short-term effects of fine particulate matter and ozone on the cardiac conduction system in patients undergoing cardiac catheterization
| Autor: | David Diaz-Sanchez, Alexandra Schneider, Siqi Zhang, Elizabeth R. Hauser, Wayne E. Cascio, Robert B. Devlin, Susanne Breitner, Joel Schwartz, Annette Peters, William E. Kraus, Lucas M. Neas |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Cardiac Catheterization Time Factors Fine particulate Health Toxicology and Mutagenesis medicine.medical_treatment Air pollution 030204 cardiovascular system & hematology 010501 environmental sciences Toxicology medicine.disease_cause 01 natural sciences Electrocardiography chemistry.chemical_compound 0302 clinical medicine Heart Rate Medicine Air Pollution Electrocardiogram Pr Interval Qt Interval Qrs Interval General Environmental Science Cardiac catheterization Air Pollutants General Medicine Middle Aged Particulates Cardiology cardiovascular system Female Electrical conduction system of the heart QT interval medicine.medical_specialty Ozone lcsh:Industrial hygiene. Industrial welfare 03 medical and health sciences QRS complex Heart Conduction System lcsh:RA1190-1270 Internal medicine Heart rate North Carolina Humans Repolarization In patient Particle Size PR interval 0105 earth and related environmental sciences lcsh:Toxicology. Poisons business.industry Research Environmental Exposure chemistry General Earth and Planetary Sciences Particulate Matter sense organs QRS interval business lcsh:HD7260-7780.8 |
| Zdroj: | Particle and Fibre Toxicology, Vol 15, Iss 1, Pp 1-9 (2018) Part. Fibre Toxicol. 15:38 (2018) Particle and Fibre Toxicology |
| ISSN: | 1743-8977 |
| Popis: | Background Air pollution-induced changes in cardiac electrophysiological properties could be a pathway linking air pollution and cardiovascular events. The evidence of air pollution effects on the cardiac conduction system is incomplete yet. We investigated short-term effects of particulate matter ≤ 2.5 μm in aerodynamic diameter (PM2.5) and ozone (O3) on cardiac electrical impulse propagation and repolarization as recorded in surface electrocardiograms (ECG). Methods We analyzed repeated 12-lead ECG measurements performed on 5,332 patients between 2001 and 2012. The participants came from the Duke CATHGEN Study who underwent cardiac catheterization and resided in North Carolina, United States (NC, U.S.). Daily concentrations of PM2.5 and O3 at each participant’s home address were predicted with a hybrid air quality exposure model. We used generalized additive mixed models to investigate the associations of PM2.5 and O3 with the PR interval, QRS interval, heart rate-corrected QT interval (QTc), and heart rate (HR). The temporal lag structures of the associations were examined using distributed-lag models. Results Elevated PM2.5 and O3 were associated with four-day lagged lengthening of the PR and QRS intervals, and with one-day lagged increases in HR. We observed immediate effects on the lengthening of the QTc interval for both PM2.5 and O3, as well as delayed effects for PM2.5 (lagged by 3 – 4 days). The associations of PM2.5 and O3 with the PR interval and the association of O3 with the QRS interval persisted until up to seven days after exposure. Conclusions In patients undergoing cardiac catheterization, short-term exposure to air pollution was associated with increased HR and delays in atrioventricular conduction, ventricular depolarization and repolarization. Electronic supplementary material The online version of this article (10.1186/s12989-018-0275-z) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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