Antioxidant, Anti-Inflammatory, and Antidiabetic Activities of Bioactive Compounds from the Fruits of Livistona chinensis Based on Network Pharmacology Prediction
| Autor: | Zhe Liu, Dan Yang, Na Han, Yuwei Wang, Li Sikai, Zhihui Liu, Jianxiu Zhai, Jun Yin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Aging
Antioxidant Article Subject medicine.drug_class medicine.medical_treatment Anti-Inflammatory Agents Arecaceae Molecular Dynamics Simulation Network Pharmacology Biochemistry Antioxidants Anti-inflammatory Compound 32 Mice chemistry.chemical_compound Nutraceutical medicine Animals Humans Glycoside Hydrolase Inhibitors IC50 Oleanolic acid Protein Tyrosine Phosphatase Non-Receptor Type 1 biology QH573-671 Plant Extracts Chemistry Macrophages Hep G2 Cells Cell Biology General Medicine biology.organism_classification Kinetics Glucose RAW 264.7 Cells Polyphenol Fruit Hepatocytes Livistona chinensis Insulin Resistance Cytology Research Article |
| Zdroj: | Oxidative Medicine and Cellular Longevity, Vol 2021 (2021) Oxidative Medicine and Cellular Longevity |
| ISSN: | 1942-0994 1942-0900 |
| Popis: | In this study, a chemical investigation on the fruits of Livistona chinensis (FLC) led to the isolation and identification of 45 polyphenols and 5 alkaloids, including two new compounds (Livischinol (1) and Livischinine A (46)), an undescribed compound (47) and 47 known compounds. FLC was predicted with novel potential antidiabetic function by collecting and analyzing the potential targets of the ingredients. Compound 32 exhibited significant α-glucosidase inhibitory activity ( I C 50 = 5.71 μM) and 1, 6, and 44 showed the PTP1B inhibitory activity with IC50 values of 9.41-22.19 μM, while that of oleanolic acid was 28.58 μM. The competitive inhibitors of PTP1B (compounds 1 and 44) formed strong binding affinity, with catalytic active sites, proved by kinetic analysis, fluorescence spectra measurements, and computational simulations, and stimulated glucose uptake in the insulin-resistant HepG2 cells at the dose of 50 μM. In addition, FLC was rich in antioxidant and anti-inflammatory bioactive compounds so that they could be developed as nutraceuticals against diabetes. |
| Databáze: | OpenAIRE |
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