[meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)ethylenediamine]- dichloroplatinum(II), a new drug not only parenterally but also orally active in the therapy of breast and prostate cancer
| Autor: | Martin R. Schneider, Kurt H. Bauer, Sabine Schertl, Helmut Schönenberger, Thilo Spruss, Ronald Gust |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Neoplasms Hormone-Dependent Organoplatinum Compounds medicine.medical_treatment Injections Subcutaneous Administration Oral Antineoplastic Agents Mice Inbred Strains Pharmacology Models Biological Rats Sprague-Dawley Subcutaneous injection Route of administration Mice Intestinal mucosa Oral administration Internal medicine medicine Animals Cisplatin Chemotherapy Gastrointestinal tract business.industry Uterus Mammary Neoplasms Experimental Prostatic Neoplasms General Medicine Organ Size Rats Endocrinology Oncology Toxicity Female business medicine.drug |
| Zdroj: | Journal of cancer research and clinical oncology. 119(12) |
| ISSN: | 0171-5216 |
| Popis: | The platinum complex [meso-1,2-bis(2,6-dichloro-4-hydroxyphenyl)- ethylenediamine]dichloroplatinum(II),K, was tested for its antitumor activity on hormone-sensitive tumor models under peroral administration. The resorption from the gastrointestinal tract was proved by determining the estrogenic effect of K in a dose/activity study using the immature-mouse uterine weight test. In comparison to the subcutaneous injection, a tenfold peroral dose was administered to achieve identical effects. By peroral treatment of the hormone-sensitive MXT(M3.2) mammary carcinoma of the mouse with K an almost complete inhibition of the tumor growth was obtained. This effect was superior to that of subcutaneously applied cisplatin and significantly better than that obtained by perorally administered ligand L at an equimolar dose, indicating that the antitumor effect is caused by the intact complex K and not by the liberated ligand L. The strong antitumor activity of perorally applied K was also demonstrated on the hormone-sensitive Noble Nb-R prostatic carcinoma of the rat. Histological examinations showed that the platinum complex K did not cause cisplatin-like kidney damage or irritations of gastric or intestinal mucosa when given perorally. |
| Databáze: | OpenAIRE |
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