Photo-biocatalytic One-Pot Cascades for the Enantioselective Synthesis of 1,3-Mercaptoalkanol Volatile Sulfur Compounds

Autor:	Simon J. Charnock, Anita Toscani, Krupa Korah, Daniele Castagnolo, Yuyin Qi, Jesmine Lim, Kate Lauder
Rok vydání:	2018
Předmět:	Aqueous medium 010405 organic chemistry Enantioselective synthesis chemistry.chemical_element General Chemistry General Medicine 010402 general chemistry Sulfur Combinatorial chemistry 01 natural sciences Catalysis 0104 chemical sciences chemistry Cascade reaction Biocatalysis Photocatalysis
Zdroj:	Lauder, K, Toscani, A, Qi, Y, Lim, J, Charnock, S J, Korah, K & Castagnolo, D 2018, ' Photo-biocatalytic One-Pot Cascades for the Enantioselective Synthesis of 1,3-Mercaptoalkanol Volatile Sulfur Compounds ', ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 57, no. 20 . https://doi.org/10.1002/anie.201802135
ISSN:	0044-8249
DOI:	10.1002/ange.201802135
Popis:	The synthesis of enantiomerically pure 1,3-mercaptoalkanol volatile sulfur compounds through a one-pot photo-biocatalytic cascade reaction is described. Two new KRED biocatalysts with opposite enantioselectivity were discovered and proved to be efficient on a wide range of substrates. The one-pot cascade reaction combining photocatalytic thio-Michael addition with biocatalytic ketoreduction in an aqueous medium provides a green and sustainable approach to enantiomerically pure 1,3-mercaptoalkanols in high yields with excellent enantioselectivity.
Databáze:	OpenAIRE
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