Differential distribution of inflammatory cells in large and small airways in smokers
| Autor: | Pieter S. Hiemstra, Vincenzo Bellia, Antonia M Vignola, Annemarie van Schadewijk, Thais Mauad, Salvatore Battaglia, Klaus F. Rabe, Peter J. Sterk |
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| Přispěvatelé: | BATTAGLIA S, MAUAD T, VAN SCHADEWIJK AM, VIGNOLA AM, RABE KF, BELLIA V, STERK PJ, HIEMSTRA PS, AII - Amsterdam institute for Infection and Immunity, Pulmonology |
| Rok vydání: | 2006 |
| Předmět: |
Male
Pathology medicine.medical_specialty Lung Neoplasms Neutrophils COPD inflammation Cell Count Inflammation Respiratory Mucosa Settore MED/10 - Malattie Dell'Apparato Respiratorio Lung injury Pathology and Forensic Medicine Smoke Humans Medicine Lymphocytes Mast Cells Respiratory system Lung cancer Lung Phagocytes Lamina propria business.industry Macrophages Smoking General Medicine Middle Aged respiratory system medicine.disease Immunohistochemistry respiratory tract diseases medicine.anatomical_structure Immunology Original Article Female medicine.symptom business Respiratory tract |
| Zdroj: | Journal of clinical pathology, 60(8), 907-911. BMJ Publishing Group |
| ISSN: | 0021-9746 |
| DOI: | 10.1136/jcp.2006.037002 |
| Popis: | BACKGROUND: Smoking induces structural changes in the airways, and is considered a major factor in the development of airflow obstruction in chronic obstructive pulmonary disease. However, differences in inflammatory cell distribution between large airways (LA) and small airways (SA) have not been systematically explored in smokers. Hypothesis: The content of cells infiltrating the airway wall differs between LA and SA. AIMS: To compare the content of neutrophils, macrophages, lymphocytes and mast cells infiltrating LA and SA in smokers who underwent surgery for lung cancer. METHODS: Lung tissue from 15 smokers was analysed. Inflammatory cells in the lamina propria were identified by immunohistochemical analysis, quantified by digital image analysis and expressed as number of cells per surface area. RESULTS: The number of neutrophils infiltrating the lamina propria of SA (median 225.3 cells/mm(2)) was higher than that in the lamina propria of LA (median 60.2 cells/mm(2); p |
| Databáze: | OpenAIRE |
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