Epstein-Barr virus-associated leiomyosarcoma of the larynx in an adult patient with human immunodeficiency virus infection: Case report and review of the literature

Autor:	Jian‐Di Jin, Zhe Chen, Zai‐Zai Cao, Shui‐Hong Zhou, Xiu‐Ming Zhang, Hong‐Tian Yao
Rok vydání:	2022
Předmět:	Adult Leiomyosarcoma Herpesvirus 4 Human Epstein-Barr Virus Infections Otorhinolaryngology Humans HIV Infections Larynx
Zdroj:	HeadneckREFERENCES. 44(12)
ISSN:	1097-0347
Popis:	We investigated the clinical features, treatment, and prognosis of laryngeal leiomyosarcoma (LLMS) and Epstein-Barr virus-associated (EBV-associated) LMS. We report a case of EBV-associated LLMS in an adult patient with HIV infection. We also conducted a review of the English-language literature on LLMS and EBV-associated leiomyosarcoma. To the best of our knowledge, 62 cases of LLMS and EBV-associated leiomyosarcoma have been reported to date. Of patients with LLS, 18.9% had distant metastases and 17.0% had local recurrence. The overall 5-year survival rate was 64.0%. Distant metastases affected the survival of patients with LLMS (p = 0.04). EBV-positive patients had a low survival rate (p = 0.01). Among patients with EBV-associated LMS, 8.2% had distant metastases and recurrence and the overall 5-year survival rate was 50.0%. EBV-associated LLMS is rare. The EBV infection might be a poor prognostic factor of LLMS.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::685925849a32449bf8fd150bd554d22f https://pubmed.ncbi.nlm.nih.gov/36069494 Zobrazit plný text záznamu Plný text