Effect of local N-acetyl-cysteine in the prevention of epidural fibrosis in rat laminectomy model

Autor: Mohammad Javad Khodayar, Masoud Zeinali, Farshid Baiatinia, Mohamad Ghanavatian, Salih Rasras, Hossein Foruozandeh, Ehsan Akbari, Mohammad Ardeshiri, Mozhdeh Mohmedi Kartalaei, Reza Bahrami, Nematollah Jazayeri
Rok vydání: 2018
Předmět:
Zdroj: Asian Journal of Neurosurgery
ISSN: 2248-9614
1793-5482
DOI: 10.4103/ajns.ajns_294_16
Popis: Background: Epidural fibrosis is a major contributing factor to the onset of failed back syndrome. Many studies have attempted to prevent this physiological response. Interestingly, N-acetyl-cysteine (NAC) has been effective in some cases in the treatment of pulmonary fibrosis. Objective: The objective of this study was to determine whether local NAC is an effective way to prevent epidural fibrosis after laminectomy in rats. Materials and Methods: Twenty Wistar rats were used in this study. Animals were divided into two groups: NAC group and a control group. We performed two-level laminectomy (L4–L5) in these rats. Rats in the control group just had laminectomy, and in the other group, L4 and L5 laminectomy followed by local treatment with NAC. Four weeks later, the rats were killed, and the laminectomy level was subjected to histopathological examination to evaluate epidural fibrosis and fibroblast density. Results: Histopathological examination showed that after 4 weeks of surgery the NAC group had significantly less epidural fibrosis and fibroblasts compared with control group. Conclusion: Our findings indicate that NAC decreased spinal epidural fibrosis after laminectomy in rats.
Databáze: OpenAIRE
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