Centrosome as a micro-electronic generator in live cell
| Autor: | Roger A. Adelman, Guogui Sun, Max Myakishev-Rempel, Johan Nygren, Jiong Li, Yue Zhao |
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| Rok vydání: | 2020 |
| Předmět: |
Statistics and Probability
2019-20 coronavirus outbreak Centriole Cell Mitosis Microtubules Models Biological General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Electromagnetic Fields 0302 clinical medicine Microtubule Slow progression medicine 030304 developmental biology Centrosome Physics 0303 health sciences Electromagnetic Radiation Applied Mathematics General Medicine Cell biology medicine.anatomical_structure Energy Transfer Modeling and Simulation Electromagnetic Phenomena 030217 neurology & neurosurgery Generator (mathematics) |
| Zdroj: | Biosystems. 197:104210 |
| ISSN: | 0303-2647 |
| DOI: | 10.1016/j.biosystems.2020.104210 |
| Popis: | Centrosome, composed of two centrioles arranged in an orthogonal configuration, is an indispensable cellular organelle for mitosis. 130 years after its discovery, the structural-functional relationship of centrosome is still obscure. Encouraged by the telltale signs of the "Mouse and Magnet experiment", Paul Schafer pioneered in the research on electromagnetism of centriole with electron microscopy(EM) in the late 1960s. Followed by the decades-long slow progression of the field with sporadic reports indicating the electromagnetisms of mitosis. Piecing together the evidences, we generated a mechanistic model for centrosome function during mitosis, in which centrosome functions as an electronic generator. In particular, the spinal rotations of centrioles transform the cellular chemical energy into cellular electromagnetic energy. The model is strongly supported by multiple experimental evidences. It offers an elegant explanation for the self-organized orthogonal configuration of the two centrioles in a centrosome, that is through the dynamic electromagnetic interactions of both centrioles of the centrosome. |
| Databáze: | OpenAIRE |
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