Polysensitization and Individual Susceptibility to Allergic Contact Dermatitis
| Autor: | Susan T. Nedorost, Brian Schmotzer, Amy L. Gosnell |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Databases Factual Hand Dermatoses Dermatology Dermatitis Atopic Cohort Studies Risk Factors medicine Genetic predisposition Humans Immunology and Allergy Hypersensitivity Delayed Allergic contact dermatitis Sensitization Retrospective Studies Individual susceptibility business.industry Patch test Retrospective cohort study Atopic dermatitis Allergens Patch Tests medicine.disease medicine.anatomical_structure Dermatitis Allergic Contact business Cohort study |
| Zdroj: | Dermatitis. 26:133-135 |
| ISSN: | 1710-3568 |
| DOI: | 10.1097/der.0000000000000111 |
| Popis: | BACKGROUND Patients with allergic contact dermatitis to 1 antigen have been shown to be at increased risk of developing delayed type hypersensitivity reactions to additional antigens. Both environmental and genetic factors likely influence the risk of sensitization. OBJECTIVE The aim of this study was to determine whether polysensitization occurs at a higher frequency than would be expected based on chance and whether polysensitization occurs more often in subsets of patients with hand involvement and atopic dermatitis. METHODS From a database of patch test results from a single practitioner, the probability of having positive reactions to 3 or more unrelated allergens was calculated under the assumption that positive reactions are independent and compared with the observed proportion having positive reactions to 3 or more unrelated allergens. The analysis was repeated excluding patients with leg involvement as a proxy for venous insufficiency dermatitis. The proportion of patients from the polysensitized and nonpolysensitized cohorts with either hand involvement or a history of atopic dermatitis was also calculated. CONCLUSIONS Polysensitization occurs more often than expected based on chance. Polysensitized patients were more likely to have hand dermatitis. Atopic dermatitis was not significantly associated with polysensitization in this analysis. Polysensitized individuals may represent a phenotype with increased genetic susceptibility to sensitization. |
| Databáze: | OpenAIRE |
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