Effect of Phenobarbitone Treatment Against Signal Grass (Brachiaria decumbens) Toxicity in Sheep
| Autor: | M.A. Rajion, H M Khairi, H.A. Elsheikh, A H Hasiah, A. S. Abdullah |
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| Rok vydání: | 2000 |
| Předmět: |
Male
Aniline Hydroxylase Sheep Diseases Crossbred sheep Kidney Poaceae Pasture Animal science Cytochrome P-450 Enzyme System Oral administration Grazing Animals Glucuronosyltransferase Enzyme inducer Glutathione Transferase Plant Poisoning chemistry.chemical_classification geography Sheep geography.geographical_feature_category General Veterinary biology Malaysia biology.organism_classification Brachiaria Enzyme Liver chemistry Biochemistry Enzyme Induction Phenobarbital Toxicity biology.protein Animal Science and Zoology Aminopyrine N-Demethylase |
| Zdroj: | The Veterinary Journal. 160:267-272 |
| ISSN: | 1090-0233 |
| DOI: | 10.1053/tvjl.2000.0498 |
| Popis: | The effect of phenobarbitone against signal grass (Brachiaria decumbens) toxicity was studied in 26 male crossbred sheep. Grazing on signal grass significantly decreased the concentration of cytochrome P-450 and the activity of drug metabolizing enzymes, viz. aminopyrine-N-demethylase, aniline-4-hydroxylase, UDP- glucuronyltransferase and glutathione-S-transferase in liver and kidneys of affected sheep. Oral administration of phenobarbitone (30 mg/kg body weight) for five consecutive days before grazing on B. decumbens pasture, and thereafter, for three consecutive days every two weeks, resulted in significant increases in hepatic and renal activities of drug-metabolizing enzymes. The induction of drug metabolizing activity in sheep grazing on signal grass group was found to be lower than in animals given phenobarbitone alone. Induction by phenobarbitone provided a degree of protection against the toxic effects of B. decumbens as indicated by the delay in the appearance of signs of toxicity. Furthermore, these were much milder compared to those in the sheep not treated with phenobarbitone. The present study suggests that phenobarbitone-type cytochrome P-450 isoenzyme-induction may increase resistance against signal grass (B. decumbens) toxicity in sheep. |
| Databáze: | OpenAIRE |
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