Early parental loss in childhood and depression in adults: A systematic review and meta-analysis of case-controlled studies
| Autor: | Zhizhong Wang, Clarisse Marie Claudine Simbi, Yuhong Zhang |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Controlled studies Parental separation Parental Death 03 medical and health sciences Young Adult 0302 clinical medicine Divorce Risk Factors Medicine Humans Risk factor Depression (differential diagnoses) business.industry Depression Random effects model 030227 psychiatry Psychiatry and Mental health Clinical Psychology Adult Survivors of Child Adverse Events Meta-analysis Case-Control Studies Female business 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Journal of affective disorders. 260 |
| ISSN: | 1573-2517 |
| Popis: | Background Many researchers have concluded that early parental loss during childhood is a risk factor for depression in late life of adults; however others didn't find any association. The objective of this systematic review is to assess whether this association exists or not by conducting a meta-analysis of published studies. Methods Nine published case-controlled studies were chosen through literature searches in PUBMED, and LIBRARY GENESIS. Newcastle-Ottawa Scale (NOS) have been used to assess the quality of studies included. Thereafter, data were extracted from each study and analysed using ProMeta. Results Nine case-controlled studies (representing n = 2784, cases=716 and controls=2068) were included in meta-analysis. The overall random effects model results of parental loss [OR = 2.18, 95% CI, 1.63–2.90, p Limitations This systematic review was limited by a small number of case-controlled studies included in meta-analysis due to the differences in methodological designs of studies. Conclusion The study concluded that parental loss, parental death, and parental separation before age 18 are risk factors of depression in adulthood. |
| Databáze: | OpenAIRE |
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