Contribution of immunoglobulin lambda light chain gene rearrangement analysis in the diagnosis of B-cell neoplasms
| Autor: | Olivier Giger, Anthony J. Bench, Ming-Qing Du, Lívia Rásó-Barnett, Yuanxue Huang, Michael A. Scott, Anna L. Paterson, Hesham Eldaly, Thomas Roberts, Hani Bibawi, Hongxiang Liu, Baljinder K Matharu, Elizabeth J. Soilleux |
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| Rok vydání: | 2018 |
| Předmět: |
Lymphoma
B-Cell Immunoglobulin lambda light chain gene Biology Polymerase Chain Reaction Clonal Immunoglobulin Gene Rearrangement 03 medical and health sciences Immunoglobulin kappa-Chains 0302 clinical medicine Immunoglobulin lambda-Chains medicine Gene Rearrangement B-Lymphocyte Light Chain Humans Gene B cell Aged Clonality Analysis Hematology Molecular biology B-cell neoplasm medicine.anatomical_structure 030220 oncology & carcinogenesis Neoplastic Stem Cells Female Genes Immunoglobulin Light Chain Neoplasm Grading Immunoglobulin Heavy Chains 030215 immunology Genes Neoplasm |
| Zdroj: | British journal of haematology. 185(2) |
| ISSN: | 1365-2141 |
| Popis: | Identification of clonal IGH, IGK and IGL gene rearrangements offers diagnostic adjunct in suspected B-cell neoplasms. However, many centres omit IGL analysis as its value is uncertain. A review of 567 cases with IGH, IGK and IGL rearrangement assessed using BIOMED-2 assays showed clonal immunoglobulin gene rearrangement in 54% of cases, of which 24% had a clonal IGL rearrangement. In two cases, the clonal rearrangement was detected exclusively by IGL analysis. This finding demonstrates the added value of IGL analysis for clonality assessment, especially in suspected B-cell neoplasms in which a clonal IGH and/or IGK rearrangement is not detected or is equivocal. |
| Databáze: | OpenAIRE |
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