Long-term outcomes of ocular adnexal lesions in IgG4-related ophthalmic disease
| Autor: | Suzuko Moritani, Masao Katayama, Reiko Nishimura, Toshinobu Kubota |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Adnexal lesions medicine.medical_treatment Lacrimal gland Extraocular muscles 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Orbital Pseudotumor medicine Long term outcomes Humans Watchful Waiting Glucocorticoids orbit Aged Retrospective Studies 030203 arthritis & rheumatology Trigeminal nerve Aged 80 and over Lacrimal Apparatus Diseases business.industry Clinical Science Middle Aged Prognosis Dermatology Sensory Systems lacrimal gland Ophthalmology medicine.anatomical_structure 030221 ophthalmology & optometry Female Immunoglobulin G4-Related Disease Ophthalmic disease business Tomography X-Ray Computed Watchful waiting Orbit (anatomy) Follow-Up Studies |
| Zdroj: | The British Journal of Ophthalmology |
| ISSN: | 1468-2079 0007-1161 |
| Popis: | AimsTo determine the long-term outcomes of ocular adnexal lesions in immunoglobulin G4-related ophthalmic disease (IgG4-ROD).MethodsThis retrospective, non-randomised exploratory study included 82 patients with ocular adnexal lesions. We evaluated the long-term outcomes in 71 patients during the median follow-up period of 30 months, who underwent either watchful waiting (n=20; range 12–90 months) or systemic corticosteroid treatment, delivered according to consensus guidelines (n=51; range 9– 115 months). We also analysed factors that might contribute to recalcitrance to treatment.ResultsOf 82 patients, 40 (49%) were male, and the median patient age was 60 years old. Twenty-one (26%) patients with extraocular muscle (EOM) and/or trigeminal nerve branch (CN V) enlargements had a significantly high frequency of multiple ocular adnexal lesions (pConclusionsThis exploratory study showed that different types of ocular adnexal lesions in IgG4-ROD displayed distinct proliferative activities. Our results suggested that EOM and/or CN V enlargements might be secondary lesions that confer refractoriness to systemic corticosteroid treatment recommended by consensus guidelines. |
| Databáze: | OpenAIRE |
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