Sesquiterpenes from the Rhizomes of Curcuma heyneana
| Autor: | Azis Saifudin, Yasuhiro Tezuka, Shigetoshi Kadota, Ken Tanaka |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Protein Tyrosine Phosphatase
Non-Receptor Type 1 Pharmacology Molecular Structure Chemistry Stereochemistry Organic Chemistry Pharmaceutical Science Protein tyrosine phosphatase Curcuma heyneana Protein Tyrosine Phosphatase 1B Analytical Chemistry Rhizome Inhibitory Concentration 50 Curcuma Complementary and alternative medicine Drug Discovery Ic50 values Molecular Medicine Inhibitory concentration 50 Procurcumenol Nuclear Magnetic Resonance Biomolecular Sesquiterpenes |
| Zdroj: | Journal of Natural Products. 76:223-229 |
| ISSN: | 1520-6025 0163-3864 |
| Popis: | Four new germacranes [heyneanones A-D (1-4)], three new guaianes [4,10-epizedoarondiol (5), 15-hydroxyprocurcumenol (6), 12-hydroxycurcumenol (7)], and two new spirolactones [curcumanolides C (8) and D (9)] were isolated from the rhizomes of Curcuma heyneana together with 13 known sesquiterpenes and two known labdane-type diterpenes. Among the isolated compounds, heyneanone A (1), heyneanone C (3), 4,10-epizedoarondiol (5), procurcumenol (16), aerugidiol (17), zerumin A (23), and (E)-15,16-bisnorlabda-8(17),11-dien-13-one (24) inhibited protein tyrosine phosphatase 1B (PTP1B) with IC(50) values of 42.5, 35.2, 35.1, 45.6, 35.7, 10.4, and 14.7 μM, respectively. |
| Databáze: | OpenAIRE |
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