Design and synthesis of a novel water soluble benzotetrazepinone
| Autor: | Daniela Vasilescu, Beatrice Dumont-Hornebeck, Yi Ning Strube, Bertrand J. Jean-Claude |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Cell Survival
Clinical Biochemistry Pharmaceutical Science Breast Neoplasms Ring (chemistry) Biochemistry Chemical synthesis Structure-Activity Relationship Breast cancer cell line Drug Discovery Tumor Cells Cultured Organic chemistry Structure–activity relationship Humans Solubility Cytotoxicity Molecular Biology Antineoplastic Agents Alkylating Aqueous solution Molecular Structure Chemistry Organic Chemistry Azepines Water soluble Drug Design Molecular Medicine Female |
| Zdroj: | Bioorganicmedicinal chemistry letters. 10(20) |
| ISSN: | 0960-894X |
| Popis: | In order to confer water solubility to the benzotetrazepinone ring system, the synthesis of 12 was undertaken. The design and synthesis of 12 were based upon previously established structural requirements for the stability of the 1,2,3,5-tetrazepin-4-one ring system. Tetrazepinone 12 was extremely water soluble and was 10-fold more potent than its imidazo-1,2,3,5-tetrazin-4-one counterpart 1a, against the human MCF-7 breast cancer cell line. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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