In search of the depressive self: extended medial prefrontal network during self-referential processing in major depression
| Autor: | Loretxu Bergouignan, Guillaume Le Bastard, Jean-François Allilaire, Cédric Lemogne, Philippe Fossati, Stéphane Lehéricy, Helen S. Mayberg, Emmanuelle Volle |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Cognitive Neuroscience Prefrontal Cortex Poison control Experimental and Cognitive Psychology Brain mapping Developmental psychology Neural Pathways Image Processing Computer-Assisted Reaction Time medicine Humans Prefrontal cortex Anterior cingulate cortex Analysis of Variance Brain Mapping Depressive Disorder Major medicine.diagnostic_test General Medicine Medial frontal gyrus Frontal gyrus Magnetic Resonance Imaging Original Papers Self Concept Oxygen Dorsolateral prefrontal cortex medicine.anatomical_structure Female Psychology Functional magnetic resonance imaging Neuroscience |
| Zdroj: | Social Cognitive and Affective Neuroscience. 4:305-312 |
| ISSN: | 1749-5024 1749-5016 |
| DOI: | 10.1093/scan/nsp008 |
| Popis: | Major depression is associated with an excessive self-focus, a tendency to engage oneself in self-referential processing. The medial frontal gyrus (MFG) is central to self-referential processing. This study aimed to explore the neural bases of this excessive self-focus and to disambiguate the role of the MFG in the pathophysiology of major depression. We presented 15 depressed patients and 15 healthy subjects with personality traits during functional magnetic resonance imaging and asked them to judge whether each trait described them (‘self’ condition) or a generally desirable trait (‘general’ condition). Both patients and healthy subjects activated the MFG in ‘self’ vs ‘general’ condition. However, the activation of the dorsal part of the MFG and of the dorsolateral prefrontal cortex (DLPFC) in ‘self’ vs ‘general’ condition was unique to patients. Additionally, patients displayed an increased functional connectivity between the MFG, the dorsal anterior cingulate cortex and the DLPFC. These results provide evidence for an extended medial prefrontal network during self-referential processing in major depression, suggesting the involvement of a greater cognitive control. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|