Development of Extended Release Divalproex Sodium Tablets Containing Hypdrophobic and Hydrophilic Matrix
| Autor: | S. Chakraborty, J. K. Pandit, A. Srinatha |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Diffusion
Biological Availability Pharmaceutical Science Methylcellulose Models Biological Excipients Matrix (chemical analysis) Hypromellose Derivatives Divalproex Sodium medicine Cellulose chemistry.chemical_classification Chromatography Chemistry Valproic Acid Hydrophilic matrix Starch Polymer Silicon Dioxide Kinetics Hydrophobic polymer Delayed-Action Preparations Drug release Fatty Alcohols Extended release Stearic Acids Tablets medicine.drug |
| Zdroj: | Current Drug Delivery. 6:291-296 |
| ISSN: | 1567-2018 |
| DOI: | 10.2174/156720109788680822 |
| Popis: | Bilayered tablets of Divalproex sodium for once-a-day administration were prepared using a hydrophilic and hydrophobic polymer as release retarding agents. This technology was found to be more effective than a simple matrix tablet with a mixture of the above polymers in order to retard the drug release for a period of 24 h. The drug release profile was strongly dependent on the presence of wicking agent, pathlength of hydrophobic layer, and hardness of tablet. f(1) value of 6.92 and f(2) value of 76.72 indicated similarity between the release profiles of batch BT3 and reference tablet (Depakote((R)) ER) with the target release of over 55% within 12 h and over 85% within 18 h. Mathematical modeling using Korsmeyer-Peppas equation indicated that the release followed a combination of diffusion and erosion mechanism. |
| Databáze: | OpenAIRE |
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